4m4z

From Proteopedia

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'''Unreleased structure'''
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{{STRUCTURE_4m4z| PDB=4m4z | SCENE= }}
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===SH3 and SH2 domains of human Src-like adaptor protein 2 (SLAP2)===
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{{ABSTRACT_PUBMED_24018043}}
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The entry 4m4z is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/SLAP2_HUMAN SLAP2_HUMAN]] Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins.
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Authors: Wybenga-Groot, L.E., McGlade, C.J.
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==About this Structure==
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[[4m4z]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M4Z OCA].
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Description: SH3 and SH2 domains of human Src-like adaptor protein 2 (SLAP2)
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==Reference==
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<ref group="xtra">PMID:024018043</ref><references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: McGlade, C J.]]
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[[Category: Wybenga-Groot, L E.]]
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[[Category: Adaptor]]
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[[Category: Sh3 and sh2 domain]]
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[[Category: Signaling protein]]

Revision as of 07:52, 6 November 2013

Template:STRUCTURE 4m4z

Contents

SH3 and SH2 domains of human Src-like adaptor protein 2 (SLAP2)

Template:ABSTRACT PUBMED 24018043

Function

[SLAP2_HUMAN] Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins.

About this Structure

4m4z is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Wybenga-Groot LE, McGlade CJ. Crystal structure of Src-like adaptor protein 2 reveals close association of SH3 and SH2 domains through beta-sheet formation. Cell Signal. 2013 Dec;25(12):2702-8. doi: 10.1016/j.cellsig.2013.08.040. Epub, 2013 Sep 7. PMID:24018043 doi:http://dx.doi.org/10.1016/j.cellsig.2013.08.040

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OCA

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