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4mfr

From Proteopedia

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'''Unreleased structure'''
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{{STRUCTURE_4mfr| PDB=4mfr | SCENE= }}
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===Crystal structure of Mycobacterium tuberculosis CarD===
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{{ABSTRACT_PUBMED_24115125}}
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The entry 4mfr is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/CARD_MYCTU CARD_MYCTU]] Controls rRNA transcription by binding to the RNA polymerase (RNAP). Required for replication and persistence during infection of mice.<ref>PMID:19596241</ref> <ref>PMID:22904282</ref>
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Authors: Kaur, G., Thakur, K.G.
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==About this Structure==
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[[4mfr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MFR OCA].
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Description: Crystal structure of Mycobacterium tuberculosis CarD
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==Reference==
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<ref group="xtra">PMID:024115125</ref><references group="xtra"/><references/>
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[[Category: Mycobacterium tuberculosis]]
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[[Category: Kaur, G.]]
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[[Category: Thakur, K G.]]
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[[Category: Five helical bundle]]
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[[Category: Rna polymerase]]
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[[Category: Transcription]]
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[[Category: Transcriptional regulator]]
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[[Category: Tudor-like domain]]

Revision as of 07:53, 6 November 2013

Template:STRUCTURE 4mfr

Contents

Crystal structure of Mycobacterium tuberculosis CarD

Template:ABSTRACT PUBMED 24115125

Function

[CARD_MYCTU] Controls rRNA transcription by binding to the RNA polymerase (RNAP). Required for replication and persistence during infection of mice.[1] [2]

About this Structure

4mfr is a 1 chain structure with sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.

Reference

  • Kaur G, Dutta D, Thakur KG. Crystal structure of Mycobacterium tuberculosis CarD, an essential RNA polymerase binding protein, reveals a quasidomain-swapped dimeric structural architecture. Proteins. 2013 Sep 30. doi: 10.1002/prot.24419. PMID:24115125 doi:http://dx.doi.org/10.1002/prot.24419
  1. ↑ Stallings CL, Stephanou NC, Chu L, Hochschild A, Nickels BE, Glickman MS. CarD is an essential regulator of rRNA transcription required for Mycobacterium tuberculosis persistence. Cell. 2009 Jul 10;138(1):146-59. doi: 10.1016/j.cell.2009.04.041. PMID:19596241 doi:10.1016/j.cell.2009.04.041
  2. ↑ Weiss LA, Harrison PG, Nickels BE, Glickman MS, Campbell EA, Darst SA, Stallings CL. Interaction of CarD with RNA polymerase mediates Mycobacterium tuberculosis viability, rifampin resistance, and pathogenesis. J Bacteriol. 2012 Oct;194(20):5621-31. Epub 2012 Aug 17. PMID:22904282 doi:10.1128/JB.00879-12

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OCA

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