1wbi

From Proteopedia

Revision as of 14:26, 30 October 2007

AVR2

Overview

BACKGROUND: The chicken avidin gene family consists of avidin and several, avidin related genes (AVRs). Of these gene products, avidin is the best, characterized and is known for its extremely high affinity for D-biotin, a, property that is utilized in numerous modern life science applications., Recently, the AVR genes have been expressed as recombinant proteins, which, have shown different biotin-binding properties as compared to avidin., RESULTS: In the present study, we have employed multiple biochemical, methods to better understand the structure-function relationship of AVR, proteins focusing on AVR2. Firstly, we have solved the high-resolution, crystal structure of AVR2 in complex with a bound ligand, D-biotin. The, AVR2 structure reveals an overall fold similar to the previously, ... [(full description)]

About this Structure

1WBI is a [Single protein] structure of sequence from [Gallus gallus] with SO4, BTN and GOL as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].

Reference

Avidin related protein 2 shows unique structural and functional features among the avidin protein family., Hytonen VP, Maatta JA, Kidron H, Halling KK, Horha J, Kulomaa T, Nyholm TK, Johnson MS, Salminen TA, Kulomaa MS, Airenne TT, BMC Biotechnol. 2005 Oct 7;5:28. PMID:16212654

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