2pw8

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'''Crystal structure of sulfo-hirudin complexed to thrombin'''<br />
'''Crystal structure of sulfo-hirudin complexed to thrombin'''<br />
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==Overview==
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==Disease==
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The leech-derived anticoagulant hirudin is post-translationally sulfated, on tyrosine 63, resulting in a &gt;10-fold increase in its affinity for, thrombin. We report the structure of a biosynthetic sulfo-hirudin, complexed to thrombin solved to 1.84 A resolution and show that sulfation, is responsible for a salt bridge and an extended hydrogen-bond network, that taken together account for the increased affinity of sulfo-hirudin, for thrombin. We also identify a divalent cation binding site at the, interface between the two subunits of alpha-thrombin that may modulate the, physiological activity of thrombin.
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Known diseases associated with this structure: Dysprothrombinemia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=176930 176930]], Hyperprothrombinemia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=176930 176930]], Hypoprothrombinemia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=176930 176930]]
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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Crystal Structure of a Biosynthetic Sulfo-hirudin Complexed to Thrombin., Liu CC, Brustad E, Liu W, Schultz PG, J Am Chem Soc. 2007 Aug 9;. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17685615 17685615]
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Crystal structure of a biosynthetic sulfo-hirudin complexed to thrombin., Liu CC, Brustad E, Liu W, Schultz PG, J Am Chem Soc. 2007 Sep 5;129(35):10648-9. Epub 2007 Aug 9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17685615 17685615]
[[Category: Hirudo medicinalis]]
[[Category: Hirudo medicinalis]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein complex]]
[[Category: Protein complex]]
[[Category: Brustad, E.]]
[[Category: Brustad, E.]]
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[[Category: Liu, C.C.]]
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[[Category: Liu, C C.]]
[[Category: Liu, W.]]
[[Category: Liu, W.]]
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[[Category: Schultz, P.G.]]
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[[Category: Schultz, P G.]]
[[Category: NA]]
[[Category: NA]]
[[Category: NI]]
[[Category: NI]]
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[[Category: thrombin]]
[[Category: thrombin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 12:33:46 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:33:49 2008''

Revision as of 16:33, 21 February 2008

Image:2pw8.jpg

2pw8, resolution 1.840Å

Drag the structure with the mouse to rotate

Crystal structure of sulfo-hirudin complexed to thrombin

Disease

Known diseases associated with this structure: Dysprothrombinemia OMIM:[176930], Hyperprothrombinemia OMIM:[176930], Hypoprothrombinemia OMIM:[176930]

About this Structure

2PW8 is a Protein complex structure of sequences from Hirudo medicinalis and Homo sapiens with and as ligands. Full crystallographic information is available from OCA.

Reference

Crystal structure of a biosynthetic sulfo-hirudin complexed to thrombin., Liu CC, Brustad E, Liu W, Schultz PG, J Am Chem Soc. 2007 Sep 5;129(35):10648-9. Epub 2007 Aug 9. PMID:17685615

Page seeded by OCA on Thu Feb 21 18:33:49 2008

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