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3qi3

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[[Image:3qi3.png|left|200px]]
 
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{{STRUCTURE_3qi3| PDB=3qi3 | SCENE= }}
{{STRUCTURE_3qi3| PDB=3qi3 | SCENE= }}
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===Crystal structure of PDE9A(Q453E) in complex with inhibitor BAY73-6691===
===Crystal structure of PDE9A(Q453E) in complex with inhibitor BAY73-6691===
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{{ABSTRACT_PUBMED_21483814}}
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{{ABSTRACT_PUBMED_21483814}}
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==Function==
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[[http://www.uniprot.org/uniprot/PDE9A_HUMAN PDE9A_HUMAN]] Hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes.<ref>PMID:18757755</ref>
==About this Structure==
==About this Structure==
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[[3qi3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QI3 OCA].
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[[3qi3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QI3 OCA].
==See Also==
==See Also==
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==Reference==
==Reference==
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<ref group="xtra">PMID:021483814</ref><references group="xtra"/>
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<ref group="xtra">PMID:021483814</ref><references group="xtra"/><references/>
[[Category: 3',5'-cyclic-GMP phosphodiesterase]]
[[Category: 3',5'-cyclic-GMP phosphodiesterase]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
[[Category: Hou, J.]]
[[Category: Hou, J.]]
[[Category: Ke, H.]]
[[Category: Ke, H.]]

Revision as of 06:18, 13 November 2013

Template:STRUCTURE 3qi3

Contents

Crystal structure of PDE9A(Q453E) in complex with inhibitor BAY73-6691

Template:ABSTRACT PUBMED 21483814

Function

[PDE9A_HUMAN] Hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes.[1]

About this Structure

3qi3 is a 2 chain structure with sequence from Human. Full crystallographic information is available from OCA.

See Also

Reference

  • Hou J, Xu J, Liu M, Zhao R, Luo HB, Ke H. Structural asymmetry of phosphodiesterase-9, potential protonation of a glutamic Acid, and role of the invariant glutamine. PLoS One. 2011 Mar 31;6(3):e18092. PMID:21483814 doi:10.1371/journal.pone.0018092
  1. ↑ Liu S, Mansour MN, Dillman KS, Perez JR, Danley DE, Aeed PA, Simons SP, Lemotte PK, Menniti FS. Structural basis for the catalytic mechanism of human phosphodiesterase 9. Proc Natl Acad Sci U S A. 2008 Sep 9;105(36):13309-14. Epub 2008 Aug 29. PMID:18757755

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