3k3e
From Proteopedia
(Difference between revisions)
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| - | [[Image:3k3e.png|left|200px]] | ||
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{{STRUCTURE_3k3e| PDB=3k3e | SCENE= }} | {{STRUCTURE_3k3e| PDB=3k3e | SCENE= }} | ||
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===Crystal structure of the PDE9A catalytic domain in complex with (R)-BAY73-6691=== | ===Crystal structure of the PDE9A catalytic domain in complex with (R)-BAY73-6691=== | ||
| + | {{ABSTRACT_PUBMED_20121115}} | ||
| - | + | ==Function== | |
| + | [[http://www.uniprot.org/uniprot/PDE9A_HUMAN PDE9A_HUMAN]] Hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes.<ref>PMID:18757755</ref> | ||
==About this Structure== | ==About this Structure== | ||
| - | [[3k3e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | [[3k3e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K3E OCA]. |
==See Also== | ==See Also== | ||
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==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:020121115</ref><references group="xtra"/> | + | <ref group="xtra">PMID:020121115</ref><references group="xtra"/><references/> |
[[Category: 3',5'-cyclic-GMP phosphodiesterase]] | [[Category: 3',5'-cyclic-GMP phosphodiesterase]] | ||
| - | [[Category: | + | [[Category: Human]] |
[[Category: Hou, J.]] | [[Category: Hou, J.]] | ||
[[Category: Ke, H.]] | [[Category: Ke, H.]] | ||
Revision as of 06:32, 13 November 2013
Contents |
Crystal structure of the PDE9A catalytic domain in complex with (R)-BAY73-6691
Template:ABSTRACT PUBMED 20121115
Function
[PDE9A_HUMAN] Hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes.[1]
About this Structure
3k3e is a 2 chain structure with sequence from Human. Full crystallographic information is available from OCA.
See Also
Reference
- Wang H, Luo X, Ye M, Hou J, Robinson H, Ke H. Insight into Binding of Phosphodiesterase-9A Selective Inhibitors by Crystal Structures and Mutagenesis. J Med Chem. 2010 Feb 1. PMID:20121115 doi:10.1021/jm901519f
- ↑ Liu S, Mansour MN, Dillman KS, Perez JR, Danley DE, Aeed PA, Simons SP, Lemotte PK, Menniti FS. Structural basis for the catalytic mechanism of human phosphodiesterase 9. Proc Natl Acad Sci U S A. 2008 Sep 9;105(36):13309-14. Epub 2008 Aug 29. PMID:18757755
Categories: 3',5'-cyclic-GMP phosphodiesterase | Human | Hou, J. | Ke, H. | Luo, X. | Robinson, H. | Wang, H. | Ye, M. | Catalytic domain | Cgmp | Hydrolase | Manganese | Metal-binding | Pde9 | Phosphoprotein
