2yjt

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==About this Structure==
==About this Structure==
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[[2yjt]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YJT OCA].
+
[[2yjt]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YJT OCA].
==Reference==
==Reference==
<ref group="xtra">PMID:024045937</ref><references group="xtra"/><references/>
<ref group="xtra">PMID:024045937</ref><references group="xtra"/><references/>
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[[Category: Escherichia coli k-12]]
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[[Category: Ecoli]]
[[Category: RNA helicase]]
[[Category: RNA helicase]]
[[Category: Hardwick, S W.]]
[[Category: Hardwick, S W.]]

Revision as of 06:35, 13 November 2013

Template:STRUCTURE 2yjt

Contents

Crystal structure of E. coli DEAD-box protein SrmB bound to regulator of ribonuclease activity A (RraA)

Template:ABSTRACT PUBMED 24045937

Function

[D8AM26_ECOLX] Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity).[HAMAP-Rule:MF_00471][SAAS:SAAS005493_004_044335] [SRMB_ECOLI] DEAD-box RNA helicase involved in the assembly of the 50S ribosomal subunit at low temperature. Exhibits RNA-stimulated ATP hydrolysis and RNA unwinding activity. Acts before DeaD.[1] [2] [3]

About this Structure

2yjt is a 4 chain structure with sequence from Ecoli. Full crystallographic information is available from OCA.

Reference

  • Pietras Z, Hardwick SW, Swiezewski S, Luisi BF. Potential regulatory interactions of Escherichia coli RraA protein with DEAD-box helicases. J Biol Chem. 2013 Sep 17. PMID:24045937 doi:10.1074/jbc.M113.502146
  1. Charollais J, Pflieger D, Vinh J, Dreyfus M, Iost I. The DEAD-box RNA helicase SrmB is involved in the assembly of 50S ribosomal subunits in Escherichia coli. Mol Microbiol. 2003 Jun;48(5):1253-65. PMID:12787353
  2. Bizebard T, Ferlenghi I, Iost I, Dreyfus M. Studies on three E. coli DEAD-box helicases point to an unwinding mechanism different from that of model DNA helicases. Biochemistry. 2004 Jun 22;43(24):7857-66. PMID:15196029 doi:10.1021/bi049852s
  3. Charollais J, Dreyfus M, Iost I. CsdA, a cold-shock RNA helicase from Escherichia coli, is involved in the biogenesis of 50S ribosomal subunit. Nucleic Acids Res. 2004 May 17;32(9):2751-9. Print 2004. PMID:15148362 doi:10.1093/nar/gkh603

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