4lmj

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{{STRUCTURE_4lmj| PDB=4lmj | SCENE= }}
{{STRUCTURE_4lmj| PDB=4lmj | SCENE= }}
===GLIC Liganded-closed-channel Conformation, Mutant T25'A===
===GLIC Liganded-closed-channel Conformation, Mutant T25'A===
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{{ABSTRACT_PUBMED_24167270}}
==Function==
==Function==
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==About this Structure==
==About this Structure==
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[[4lmj]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Gloeobacter_violaceus Gloeobacter violaceus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LMJ OCA].
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[[4lmj]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Glovo Glovo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LMJ OCA].
==Reference==
==Reference==
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<references group="xtra"/><references/>
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<ref group="xtra">PMID:024167270</ref><references group="xtra"/><references/>
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[[Category: Gloeobacter violaceus]]
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[[Category: Glovo]]
[[Category: Gonzalez-Gutierrez, G.]]
[[Category: Gonzalez-Gutierrez, G.]]
[[Category: Grosman, C.]]
[[Category: Grosman, C.]]

Revision as of 06:40, 13 November 2013

Template:STRUCTURE 4lmj

Contents

GLIC Liganded-closed-channel Conformation, Mutant T25'A

Template:ABSTRACT PUBMED 24167270

Function

[GLIC_GLOVI] Cationic channel with similar permeabilities for Na(+) and K(+), that is activated by an increase of the proton concentration on the extracellular side. Displays no permeability for chloride ions. Shows slow kinetics of activation, no desensitization and a single channel conductance of 8 pS. Might contribute to adaptation to external pH change.[1]

About this Structure

4lmj is a 5 chain structure with sequence from Glovo. Full crystallographic information is available from OCA.

Reference

  • Gonzalez-Gutierrez G, Cuello LG, Nair SK, Grosman C. Gating of the proton-gated ion channel from Gloeobacter violaceus at pH 4 as revealed by X-ray crystallography. Proc Natl Acad Sci U S A. 2013 Oct 28. PMID:24167270 doi:http://dx.doi.org/10.1073/pnas.1313156110
  1. ↑ Bocquet N, Prado de Carvalho L, Cartaud J, Neyton J, Le Poupon C, Taly A, Grutter T, Changeux JP, Corringer PJ. A prokaryotic proton-gated ion channel from the nicotinic acetylcholine receptor family. Nature. 2007 Jan 4;445(7123):116-9. Epub 2006 Dec 10. PMID:17167423 doi:10.1038/nature05371

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