4c11

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==About this Structure==
==About this Structure==
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[[4c11]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus Dengue virus] and [http://en.wikipedia.org/wiki/Zasmidium_angulare Zasmidium angulare]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C11 OCA].
+
[[4c11]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus Dengue virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C11 OCA].
==Reference==
==Reference==
<ref group="xtra">PMID:024025331</ref><references group="xtra"/><references/>
<ref group="xtra">PMID:024025331</ref><references group="xtra"/><references/>
[[Category: Dengue virus]]
[[Category: Dengue virus]]
-
[[Category: Zasmidium angulare]]
 
[[Category: Lescar, J.]]
[[Category: Lescar, J.]]
[[Category: Lim, S P.]]
[[Category: Lim, S P.]]
[[Category: Rna dependent rna polymerase]]
[[Category: Rna dependent rna polymerase]]
[[Category: Transferase]]
[[Category: Transferase]]

Revision as of 06:47, 13 November 2013

Template:STRUCTURE 4c11

Contents

Dengue virus RNA dependent RNA polymerase with residues from the NS5 linker region

Template:ABSTRACT PUBMED 24025331

Function

[Q6DLV0_9FLAV] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS000336_004_099774]

About this Structure

4c11 is a 2 chain structure with sequence from Dengue virus. Full crystallographic information is available from OCA.

Reference

  • Lim SP, Koh JH, Seh CC, Liew CW, Davidson AD, Chua LS, Chandrasekaran R, Cornvik TC, Shi PY, Lescar J. A crystal structure of the Dengue virus NS5 polymerase delineates inter-domain amino acids residues that enhance its thermostability and de novo initiation activities. J Biol Chem. 2013 Sep 11. PMID:24025331 doi:10.1074/jbc.M113.508606

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