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-	'''Unreleased structure'''	+	{{STRUCTURE_4ivs| PDB=4ivs | SCENE= }}
		+	===Crystal structure of BACE1 with its inhibitor===
		+	{{ABSTRACT_PUBMED_23681056}}
-	The entry 4ivs is ON HOLD until Paper Publication	+	==Function==
		+	[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
-	Authors: Chen, T.T., Li, L., Chen, W.Y., Xu, Y.C.	+	==About this Structure==
		+	[[4ivs]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IVS OCA].
-	Description: Crystal structure of BACE1 with its inhibitor	+	==Reference==
		+	<ref group="xtra">PMID:023681056</ref><references group="xtra"/><references/>
		+	[[Category: Memapsin 2]]
		+	[[Category: Chen, T T.]]
		+	[[Category: Chen, W Y.]]
		+	[[Category: Li, L.]]
		+	[[Category: Xu, Y C.]]
		+	[[Category: Hydrolase]]
		+	[[Category: Hydrolase-hydrolase inhibitor complex]]

---

Revision as of 08:14, 13 November 2013

spinqualitylabelsall models PDB ID 4ivs Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
4ivs, resolution 2.64Å ()
Ligands:
Activity:	Memapsin 2, with EC number 3.4.23.46
Related:	4ivt
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml

Contents 1 Crystal structure of BACE1 with its inhibitor 2 Function 3 About this Structure 4 Reference

Crystal structure of BACE1 with its inhibitor

Template:ABSTRACT PUBMED 23681056

Function

[BACE1_HUMAN] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.^{[1] [2]}

About this Structure

4ivs is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

• Zou Y, Li L, Chen W, Chen T, Ma L, Wang X, Xiong B, Xu Y, Shen J. Virtual screening and structure-based discovery of indole acylguanidines as potent beta-secretase (BACE1) inhibitors. Molecules. 2013 May 16;18(5):5706-22. doi: 10.3390/molecules18055706. PMID:23681056 doi:http://dx.doi.org/10.3390/molecules18055706

1. ↑ Lin X, Koelsch G, Wu S, Downs D, Dashti A, Tang J. Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein. Proc Natl Acad Sci U S A. 2000 Feb 15;97(4):1456-60. PMID:10677483
2. ↑ Okada H, Zhang W, Peterhoff C, Hwang JC, Nixon RA, Ryu SH, Kim TW. Proteomic identification of sorting nexin 6 as a negative regulator of BACE1-mediated APP processing. FASEB J. 2010 Aug;24(8):2783-94. doi: 10.1096/fj.09-146357. Epub 2010 Mar 30. PMID:20354142 doi:10.1096/fj.09-146357