4c5h

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'''Unreleased structure'''
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{{STRUCTURE_4c5h| PDB=4c5h | SCENE= }}
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===Crystal structure of the minimal Pho-Sfmbt complex (P3121 spacegroup)===
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{{ABSTRACT_PUBMED_24186981}}
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The entry 4c5h is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/SMBT_DROME SMBT_DROME]] Polycomb group (PcG) protein that binds to the Polycomb response elements (PREs) found in the regulatory regions of many genes. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility. Necessary but not sufficient to recruit a functional PcG repressive complex that represses target genes, suggesting that the recruitment of the distinct PRC1 complex is also required to allow a subsequent repression.<ref>PMID:16618800</ref> [[http://www.uniprot.org/uniprot/PHO_DROME PHO_DROME]] Polycomb group (PcG) protein that binds to the 5'-CNGCCATNNNNG-3' sequence found in the regulatory regions of many genes. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility. Probably targets the Esc/E(z) complex to DNA. Necessary but not sufficient to recruit a functional PcG repressive complex that represses target genes, suggesting that the recruitment of the distinct PRC1 complex is also required to allow a subsequent repression.<ref>PMID:9651589</ref> <ref>PMID:10433918</ref> Proposed core component of the chromatin remodeling Ino80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair (By similarity).<ref>PMID:9651589</ref> <ref>PMID:10433918</ref>
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Authors: Alfieri, C., Glatt, S., Mueller, C.W.
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==About this Structure==
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[[4c5h]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C5H OCA].
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Description: Crystal structure of the minimal Pho-Sfmbt complex (P3121 spacegroup)
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==Reference==
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<ref group="xtra">PMID:024186981</ref><references group="xtra"/><references/>
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[[Category: Alfieri, C.]]
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[[Category: Glatt, S.]]
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[[Category: Mueller, C W.]]
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[[Category: Transcription]]

Revision as of 08:14, 13 November 2013

Template:STRUCTURE 4c5h

Contents

Crystal structure of the minimal Pho-Sfmbt complex (P3121 spacegroup)

Template:ABSTRACT PUBMED 24186981

Function

[SMBT_DROME] Polycomb group (PcG) protein that binds to the Polycomb response elements (PREs) found in the regulatory regions of many genes. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility. Necessary but not sufficient to recruit a functional PcG repressive complex that represses target genes, suggesting that the recruitment of the distinct PRC1 complex is also required to allow a subsequent repression.[1] [PHO_DROME] Polycomb group (PcG) protein that binds to the 5'-CNGCCATNNNNG-3' sequence found in the regulatory regions of many genes. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility. Probably targets the Esc/E(z) complex to DNA. Necessary but not sufficient to recruit a functional PcG repressive complex that represses target genes, suggesting that the recruitment of the distinct PRC1 complex is also required to allow a subsequent repression.[2] [3] Proposed core component of the chromatin remodeling Ino80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair (By similarity).[4] [5]

About this Structure

4c5h is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  • Alfieri C, Gambetta MC, Matos R, Glatt S, Sehr P, Fraterman S, Wilm M, Muller J, Muller CW. Structural basis for targeting the chromatin repressor Sfmbt to Polycomb response elements. Genes Dev. 2013 Nov 1;27(21):2367-79. doi: 10.1101/gad.226621.113. PMID:24186981 doi:http://dx.doi.org/10.1101/gad.226621.113
  1. ↑ Klymenko T, Papp B, Fischle W, Kocher T, Schelder M, Fritsch C, Wild B, Wilm M, Muller J. A Polycomb group protein complex with sequence-specific DNA-binding and selective methyl-lysine-binding activities. Genes Dev. 2006 May 1;20(9):1110-22. Epub 2006 Apr 17. PMID:16618800 doi:http://dx.doi.org/10.1101/gad.377406
  2. ↑ Brown JL, Mucci D, Whiteley M, Dirksen ML, Kassis JA. The Drosophila Polycomb group gene pleiohomeotic encodes a DNA binding protein with homology to the transcription factor YY1. Mol Cell. 1998 Jun;1(7):1057-64. PMID:9651589
  3. ↑ Fritsch C, Brown JL, Kassis JA, Muller J. The DNA-binding polycomb group protein pleiohomeotic mediates silencing of a Drosophila homeotic gene. Development. 1999 Sep;126(17):3905-13. PMID:10433918
  4. ↑ Brown JL, Mucci D, Whiteley M, Dirksen ML, Kassis JA. The Drosophila Polycomb group gene pleiohomeotic encodes a DNA binding protein with homology to the transcription factor YY1. Mol Cell. 1998 Jun;1(7):1057-64. PMID:9651589
  5. ↑ Fritsch C, Brown JL, Kassis JA, Muller J. The DNA-binding polycomb group protein pleiohomeotic mediates silencing of a Drosophila homeotic gene. Development. 1999 Sep;126(17):3905-13. PMID:10433918

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