2m9y

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-	'''Unreleased structure'''	+	{{STRUCTURE_2m9y| PDB=2m9y | SCENE= }}
		+	===Solution Structure of the Catalytic Domain of HHARI===
		+	{{ABSTRACT_PUBMED_24058416}}
-	The entry 2m9y is ON HOLD	+	==Function==
		+	[[http://www.uniprot.org/uniprot/ARI1_HUMAN ARI1_HUMAN]] E3 ubiquitin-protein ligase, which catalyzes polyubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3. May play a role in protein translation by mediating polyubiquitination of EIF4E2, leading to its subsequent degradation.<ref>PMID:14623119</ref> <ref>PMID:21532592</ref> <ref>PMID:15236971</ref>
-	Authors: Mercier, P., Spratt, D.E., Shaw, G.S.	+	==About this Structure==
		+	[[2m9y]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M9Y OCA].
-	Description: Solution Structure of the Catalytic Domain of HHARI	+	==Reference==
		+	<ref group="xtra">PMID:024058416</ref><references group="xtra"/><references/>
		+	[[Category: Mercier, P.]]
		+	[[Category: Shaw, G S.]]
		+	[[Category: Spratt, D E.]]
		+	[[Category: E3 ligase]]
		+	[[Category: Hhari]]
		+	[[Category: Ligase]]
		+	[[Category: Ring2]]
		+	[[Category: Zn-binding]]

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Revision as of 08:15, 13 November 2013

Template:STRUCTURE 2m9y

Contents 1 Solution Structure of the Catalytic Domain of HHARI 2 Function 3 About this Structure 4 Reference

Solution Structure of the Catalytic Domain of HHARI

Template:ABSTRACT PUBMED 24058416

Function

[ARI1_HUMAN] E3 ubiquitin-protein ligase, which catalyzes polyubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3. May play a role in protein translation by mediating polyubiquitination of EIF4E2, leading to its subsequent degradation.^{[1] [2] [3]}

About this Structure

2m9y is a 1 chain structure. Full experimental information is available from OCA.

Reference

• Spratt DE, Mercier P, Shaw GS. Structure of the HHARI catalytic domain shows glimpses of a HECT E3 ligase. PLoS One. 2013 Aug 15;8(8):e74047. doi: 10.1371/journal.pone.0074047. PMID:24058416 doi:http://dx.doi.org/10.1371/journal.pone.0074047

1. ↑ Tan NG, Ardley HC, Scott GB, Rose SA, Markham AF, Robinson PA. Human homologue of ariadne promotes the ubiquitylation of translation initiation factor 4E homologous protein, 4EHP. FEBS Lett. 2003 Nov 20;554(3):501-4. PMID:14623119
2. ↑ Wenzel DM, Lissounov A, Brzovic PS, Klevit RE. UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids. Nature. 2011 Jun 2;474(7349):105-8. doi: 10.1038/nature09966. Epub 2011 May 1. PMID:21532592 doi:10.1038/nature09966
3. ↑ Capili AD, Edghill EL, Wu K, Borden KL. Structure of the C-terminal RING finger from a RING-IBR-RING/TRIAD motif reveals a novel zinc-binding domain distinct from a RING. J Mol Biol. 2004 Jul 23;340(5):1117-29. PMID:15236971 doi:10.1016/j.jmb.2004.05.035