3wjl

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m (Protected "3wjl" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_3wjl| PDB=3wjl | SCENE= }}
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===Crystal structure of IIb selective Fc variant, Fc(V12), in complex with FcgRIIb===
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{{ABSTRACT_PUBMED_23744091}}
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The entry 3wjl is ON HOLD
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==Disease==
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[[http://www.uniprot.org/uniprot/IGHG1_HUMAN IGHG1_HUMAN]] Defects in IGHG1 are a cause of multiple myeloma (MM) [MIM:[http://omim.org/entry/254500 254500]]. MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. Note=A chromosomal aberration involving IGHG1 is found in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus. Translocation t(11;14)(q13;q32) with CCND1; translocation t(4;14)(p16.3;q32.3) with FGFR3; translocation t(6;14)(p25;q32) with IRF4.
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Authors: Kadono, S., Mimoto, F., Katada, H., Igawa, T., Kuramochi, T., Muraoka, M., Wada, Y., Haraya, K., Miyazaki, T., Hattori, K.
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==Function==
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[[http://www.uniprot.org/uniprot/FCG2C_HUMAN FCG2C_HUMAN]] Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells.
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Description: Crystal structure of IIb selective Fc variant, Fc(V12), in complex with FcgRIIb
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==About this Structure==
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[[3wjl]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WJL OCA].
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==Reference==
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<ref group="xtra">PMID:023744091</ref><references group="xtra"/><references/>
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[[Category: Haraya, K.]]
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[[Category: Hattori, K.]]
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[[Category: Igawa, T.]]
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[[Category: Kadono, S.]]
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[[Category: Katada, H.]]
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[[Category: Kuramochi, T.]]
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[[Category: Mimoto, F.]]
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[[Category: Miyazaki, T.]]
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[[Category: Muraoka, M.]]
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[[Category: Wada, Y.]]
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[[Category: Antibody]]
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[[Category: Fc receptor]]
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[[Category: Immune system]]
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[[Category: Receptor complex]]

Revision as of 08:15, 13 November 2013

Template:STRUCTURE 3wjl

Contents

Crystal structure of IIb selective Fc variant, Fc(V12), in complex with FcgRIIb

Template:ABSTRACT PUBMED 23744091

Disease

[IGHG1_HUMAN] Defects in IGHG1 are a cause of multiple myeloma (MM) [MIM:254500]. MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. Note=A chromosomal aberration involving IGHG1 is found in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus. Translocation t(11;14)(q13;q32) with CCND1; translocation t(4;14)(p16.3;q32.3) with FGFR3; translocation t(6;14)(p25;q32) with IRF4.

Function

[FCG2C_HUMAN] Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells.

About this Structure

3wjl is a 3 chain structure. Full crystallographic information is available from OCA.

Reference

  • Mimoto F, Katada H, Kadono S, Igawa T, Kuramochi T, Muraoka M, Wada Y, Haraya K, Miyazaki T, Hattori K. Engineered antibody Fc variant with selectively enhanced FcgammaRIIb binding over both FcgammaRIIa(R131) and FcgammaRIIa(H131). Protein Eng Des Sel. 2013 Oct;26(10):589-98. doi: 10.1093/protein/gzt022. Epub, 2013 Jun 5. PMID:23744091 doi:http://dx.doi.org/10.1093/protein/gzt022

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OCA

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