4c51

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "4c51" [edit=sysop:move=sysop])
Line 1: Line 1:
-
'''Unreleased structure'''
+
{{STRUCTURE_4c51| PDB=4c51 | SCENE= }}
 +
===Crystal Structure of the Catalase-Peroxidase (KatG) R418L mutant from Mycobacterium Tuberculosis===
 +
{{ABSTRACT_PUBMED_24185282}}
-
The entry 4c51 is ON HOLD until Paper Publication
+
==Function==
 +
[[http://www.uniprot.org/uniprot/KATG_MYCTU KATG_MYCTU]] Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity. Displays also NADH oxidase, isoniazid (INH) lyase and isonicotinoyl-NAD synthase activity. May play a role in the intracellular survival of mycobacteria. May be involved in DNA repair. Partly complements recA-deficient E.coli cells exposed to UV radiation, mitomycin C or hydrogen peroxide. Increases resistance to mitomycin C in E.coli cells deficient for either uvrA, uvrB or uvrC.<ref>PMID:10463167</ref>
-
Authors: Hersleth, H.-P., Zhao, X., Magliozzo, R.S., Andersson, K.K.
+
==About this Structure==
 +
[[4c51]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C51 OCA].
-
Description: Crystal Structure of the Catalase-Peroxidase (KatG) R418L mutant from Mycobacterium Tuberculosis
+
==Reference==
 +
<ref group="xtra">PMID:024185282</ref><references group="xtra"/><references/>
 +
[[Category: Catalase peroxidase]]
 +
[[Category: Andersson, K K.]]
 +
[[Category: Hersleth, H P.]]
 +
[[Category: Magliozzo, R S.]]
 +
[[Category: Zhao, X.]]
 +
[[Category: Oxidoreductase]]

Revision as of 08:15, 13 November 2013

Template:STRUCTURE 4c51

Contents

Crystal Structure of the Catalase-Peroxidase (KatG) R418L mutant from Mycobacterium Tuberculosis

Template:ABSTRACT PUBMED 24185282

Function

[KATG_MYCTU] Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity. Displays also NADH oxidase, isoniazid (INH) lyase and isonicotinoyl-NAD synthase activity. May play a role in the intracellular survival of mycobacteria. May be involved in DNA repair. Partly complements recA-deficient E.coli cells exposed to UV radiation, mitomycin C or hydrogen peroxide. Increases resistance to mitomycin C in E.coli cells deficient for either uvrA, uvrB or uvrC.[1]

About this Structure

4c51 is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  • Zhao X, Hersleth HP, Zhu J, Andersson KK, Magliozzo RS. Access channel residues Ser315 and Asp137 in Mycobacterium tuberculosis catalase-peroxidase (KatG) control peroxidatic activation of the pro-drug isoniazid. Chem Commun (Camb). 2013 Nov 4. PMID:24185282 doi:http://dx.doi.org/10.1039/c3cc47022a
  1. ↑ Mulder MA, Nair S, Abratt VR, Zappe H, Steyn LM. Involvement of the N- and C-terminal domains of Mycobacterium tuberculosis KatG in the protection of mutant Escherichia coli against DNA-damaging agents. Microbiology. 1999 Aug;145 ( Pt 8):2011-21. PMID:10463167

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4c51"
Personal tools