4ihh

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'''Unreleased structure'''
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{{STRUCTURE_4ihh| PDB=4ihh | SCENE= }}
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===Chasing Acyl Carrier Protein Through a Catalytic Cycle of Lipid A Production===
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The entry 4ihh is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/LPXD_ECOLI LPXD_ECOLI]] Catalyzes the N-acylation of UDP-3-O-(hydroxymyristoyl)glucosamine using 3-hydroxymyristoyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Prefers R-3-hydroxymyristoyl-ACP over R-3-hydroxypalmitoyl-ACP as the acyl donor in vitro, which is consistent with the structure of E.coli lipid A that contains over 95% (R)-3-hydroxymyristate at the 2 and 2' positions.<ref>PMID:8444173</ref> <ref>PMID:19655786</ref> [[http://www.uniprot.org/uniprot/G7RM21_ECOC1 G7RM21_ECOC1]] Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity).[HAMAP-Rule:MF_01217][RuleBase:RU003545]
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Authors: Masoudi, A., Raetz, C.R.H., Pemble, C.W.
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==About this Structure==
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[[4ihh]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IHH OCA].
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Description: Structural Basis for Acyl-substrate Delivery and Product Release by ACP in the Biosynthesis of Lipid A
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Masoudi, A.]]
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[[Category: Pemble, C W.]]
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[[Category: Raetz, C R.H.]]
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[[Category: Acp mediated product release]]
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[[Category: Acp recognition domain]]
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[[Category: Acyl carrier protein]]
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[[Category: Acyltransferase]]
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[[Category: Left handed beta helix]]
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[[Category: Lipid some]]
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[[Category: Lpxd]]
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[[Category: Protein-protein complex]]
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[[Category: Transferase-lipid binding protein complex]]

Revision as of 08:28, 13 November 2013

Template:STRUCTURE 4ihh

Contents

Chasing Acyl Carrier Protein Through a Catalytic Cycle of Lipid A Production

Function

[LPXD_ECOLI] Catalyzes the N-acylation of UDP-3-O-(hydroxymyristoyl)glucosamine using 3-hydroxymyristoyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Prefers R-3-hydroxymyristoyl-ACP over R-3-hydroxypalmitoyl-ACP as the acyl donor in vitro, which is consistent with the structure of E.coli lipid A that contains over 95% (R)-3-hydroxymyristate at the 2 and 2' positions.[1] [2] [G7RM21_ECOC1] Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity).[HAMAP-Rule:MF_01217][RuleBase:RU003545]

About this Structure

4ihh is a 12 chain structure. Full crystallographic information is available from OCA.

Reference

  1. ↑ Helander IM, Lindner B, Seydel U, Vaara M. Defective biosynthesis of the lipid A component of temperature-sensitive firA (omsA) mutant of Escherichia coli. Eur J Biochem. 1993 Mar 1;212(2):363-9. PMID:8444173
  2. ↑ Bartling CM, Raetz CR. Crystal Structure and Acyl Chain Selectivity of Escherichia coli LpxD, the N-Acyltransferase of Lipid A Biosynthesis. Biochemistry. 2009 Aug 5. PMID:19655786 doi:10.1021/bi901025v

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