4mql

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "4mql" [edit=sysop:move=sysop])
Line 1: Line 1:
-
'''Unreleased structure'''
+
{{STRUCTURE_4mql| PDB=4mql | SCENE= }}
 +
===Crystal structure of Antigen 85C-C209S mutant===
-
The entry 4mql is ON HOLD
+
==Function==
 +
[[http://www.uniprot.org/uniprot/A85C_MYCTU A85C_MYCTU]] The antigen 85 proteins (FbpA, FbpB, FbpC) are responsible for the high affinity of mycobacteria to fibronectin, a large adhesive glycoprotein, which facilitates the attachment of M.tuberculosis to murine alveolar macrophages (AMs). They also help to maintain the integrity of the cell wall by catalyzing the transfer of mycolic acids to cell wall arabinogalactan and through the synthesis of alpha,alpha-trehalose dimycolate (TDM, cord factor). They catalyze the transfer of a mycoloyl residue from one molecule of alpha,alpha-trehalose monomycolate (TMM) to another TMM, leading to the formation of TDM.<ref>PMID:1830294</ref> <ref>PMID:9162010</ref>
-
Authors: Favrot, L., Grzegorzewicz, A.E., Lajiness, D.H., Marvin, R.K., Boucau, J., Isailovic, D., Jackson, M., Ronning, D.R.
+
==About this Structure==
 +
[[4mql]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MQL OCA].
-
Description: Crystal structure of Antigen 85C-C209S mutant
+
==Reference==
 +
<references group="xtra"/><references/>
 +
[[Category: Boucau, J.]]
 +
[[Category: Favrot, L.]]
 +
[[Category: Grzegorzewicz, A E.]]
 +
[[Category: Isailovic, D.]]
 +
[[Category: Jackson, M.]]
 +
[[Category: Lajiness, D H.]]
 +
[[Category: Marvin, R K.]]
 +
[[Category: Ronning, D R.]]
 +
[[Category: Acyltransferase]]
 +
[[Category: Transferase]]

Revision as of 08:32, 13 November 2013

Template:STRUCTURE 4mql

Contents

Crystal structure of Antigen 85C-C209S mutant

Function

[A85C_MYCTU] The antigen 85 proteins (FbpA, FbpB, FbpC) are responsible for the high affinity of mycobacteria to fibronectin, a large adhesive glycoprotein, which facilitates the attachment of M.tuberculosis to murine alveolar macrophages (AMs). They also help to maintain the integrity of the cell wall by catalyzing the transfer of mycolic acids to cell wall arabinogalactan and through the synthesis of alpha,alpha-trehalose dimycolate (TDM, cord factor). They catalyze the transfer of a mycoloyl residue from one molecule of alpha,alpha-trehalose monomycolate (TMM) to another TMM, leading to the formation of TDM.[1] [2]

About this Structure

4mql is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  1. ↑ Abou-Zeid C, Garbe T, Lathigra R, Wiker HG, Harboe M, Rook GA, Young DB. Genetic and immunological analysis of Mycobacterium tuberculosis fibronectin-binding proteins. Infect Immun. 1991 Aug;59(8):2712-8. PMID:1830294
  2. ↑ Belisle JT, Vissa VD, Sievert T, Takayama K, Brennan PJ, Besra GS. Role of the major antigen of Mycobacterium tuberculosis in cell wall biogenesis. Science. 1997 May 30;276(5317):1420-2. PMID:9162010

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4mql"
Personal tools