3id6
From Proteopedia
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===Crystal structure of Sulfolobus solfataricus Nop5 (1-262) and fibrillarin complex=== | ===Crystal structure of Sulfolobus solfataricus Nop5 (1-262) and fibrillarin complex=== | ||
{{ABSTRACT_PUBMED_19666563}} | {{ABSTRACT_PUBMED_19666563}} | ||
| + | |||
| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/FLPA_SULSO FLPA_SULSO]] Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.<ref>PMID:11959980</ref> <ref>PMID:15522081</ref> | ||
==About this Structure== | ==About this Structure== | ||
| - | [[3id6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | [[3id6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_35091 Atcc 35091]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ID6 OCA]. |
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:019666563</ref><references group="xtra"/> | + | <ref group="xtra">PMID:019666563</ref><references group="xtra"/><references/> |
| - | [[Category: | + | [[Category: Atcc 35091]] |
[[Category: Ye, K.]] | [[Category: Ye, K.]] | ||
[[Category: 2'-o-methylation]] | [[Category: 2'-o-methylation]] | ||
Revision as of 11:35, 20 November 2013
Contents |
Crystal structure of Sulfolobus solfataricus Nop5 (1-262) and fibrillarin complex
Template:ABSTRACT PUBMED 19666563
Function
[FLPA_SULSO] Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.[1] [2]
About this Structure
3id6 is a 2 chain structure with sequence from Atcc 35091. Full crystallographic information is available from OCA.
Reference
- Ye K, Jia R, Lin J, Ju M, Peng J, Xu A, Zhang L. Structural organization of box C/D RNA-guided RNA methyltransferase. Proc Natl Acad Sci U S A. 2009 Aug 5. PMID:19666563
- ↑ Omer AD, Ziesche S, Ebhardt H, Dennis PP. In vitro reconstitution and activity of a C/D box methylation guide ribonucleoprotein complex. Proc Natl Acad Sci U S A. 2002 Apr 16;99(8):5289-94. PMID:11959980 doi:http://dx.doi.org/10.1073/pnas.082101999
- ↑ Ziesche SM, Omer AD, Dennis PP. RNA-guided nucleotide modification of ribosomal and non-ribosomal RNAs in Archaea. Mol Microbiol. 2004 Nov;54(4):980-93. PMID:15522081 doi:http://dx.doi.org/MMI4319
