3zg3
From Proteopedia
(Difference between revisions)
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==About this Structure== | ==About this Structure== | ||
| - | [[3zg3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | [[3zg3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Trycr Trycr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZG3 OCA]. |
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:024047900</ref><references group="xtra"/><references/> | <ref group="xtra">PMID:024047900</ref><references group="xtra"/><references/> | ||
[[Category: Sterol 14-demethylase]] | [[Category: Sterol 14-demethylase]] | ||
| - | [[Category: | + | [[Category: Trycr]] |
[[Category: Chatelain, E.]] | [[Category: Chatelain, E.]] | ||
[[Category: Hargrove, T Y.]] | [[Category: Hargrove, T Y.]] | ||
Revision as of 11:42, 20 November 2013
Contents |
STEROL 14-ALPHA DEMETHYLASE (CYP51)FROM TRYPANOSOMA CRUZI IN COMPLEX WITH THE PYRIDINE INHIBITOR N-(1-(5-(trifluoromethyl)(pyridin-2-yl)) piperidin-4yl)-N-(4-(trifluoromethyl)phenyl)pyridin-3-amine (EPL- BS967, UDD)
Template:ABSTRACT PUBMED 24047900
Function
[CP51_TRYCC] Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol (By similarity). Favors C4 dimethylated substrates, the substrate preference order is 24-methylenedihydrolanosterol > 24,25-dihydrolanosterol > lanosterol > obtusifoliol > norlanosterol.[1] [UniProtKB:P0A512]
About this Structure
3zg3 is a 1 chain structure with sequence from Trycr. Full crystallographic information is available from OCA.
Reference
- Hargrove TY, Wawrzak Z, Alexander PW, Chaplin JH, Keenan M, Charman SA, Perez CJ, Waterman MR, Chatelain E, Lepesheva GI. Complexes of Trypanosoma cruzi sterol 14alpha-demethylase (CYP51) with two pyridine-based drug candidates for Chagas disease: Structural basis for pathogen-selectivity. J Biol Chem. 2013 Sep 18. PMID:24047900 doi:10.1074/jbc.M113.497990
- ↑ Lepesheva GI, Zaitseva NG, Nes WD, Zhou W, Arase M, Liu J, Hill GC, Waterman MR. CYP51 from Trypanosoma cruzi: a phyla-specific residue in the B' helix defines substrate preferences of sterol 14alpha-demethylase. J Biol Chem. 2006 Feb 10;281(6):3577-85. Epub 2005 Nov 30. PMID:16321980 doi:M510317200
