1umr

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[[Image:1umr.png|left|200px]]
 
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{{STRUCTURE_1umr| PDB=1umr | SCENE= }}
{{STRUCTURE_1umr| PDB=1umr | SCENE= }}
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===Crystal structure of the platelet activator convulxin, a disulfide linked a4b4 cyclic tetramer from the venom of Crotalus durissus terrificus===
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{{ABSTRACT_PUBMED_14521935}}
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===CRYSTAL STRUCTURE OF THE PLATELET ACTIVATOR CONVULXIN, A DISULFIDE LINKED A4B4 CYCLIC TETRAMER FROM THE VENOM OF CROTALUS DURISSUS TERRIFICUS===
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==Function==
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[[http://www.uniprot.org/uniprot/SLA_CRODU SLA_CRODU]] Snake venom lectin that activates platelets by binding to the platelet collagen receptor glycoprotein VI (GP6) (PubMed:9153205). The indirect activation of integrin alpha-IIb/beta-3 (ITGA2B/ITGB3) also induced by the toxin is upstream the cytoskeletal translocation of GPIb, FcRgamma (FCER1G) and 14-3-3zeta (YWHAZ)(PubMed:16102113).<ref>PMID:9153205</ref> <ref>PMID:16102113</ref> [[http://www.uniprot.org/uniprot/SLB_CRODU SLB_CRODU]] Snake venom lectin that activates platelets by binding to the platelet collagen receptor glycoprotein VI (GP6) (PubMed:9153205). The indirect activation of integrin alpha-IIb/beta-3 (ITGA2B/ITGB3) also induced by the toxin is upstream the cytoskeletal translocation of GPIb, FcRgamma (FCER1G) and 14-3-3zeta (YWHAZ)(PubMed:16102113).<ref>PMID:9153205</ref> <ref>PMID:16102113</ref>
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{{ABSTRACT_PUBMED_14521935}}
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==About this Structure==
==About this Structure==
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[[1umr]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Crotalus_durissus_terrificus Crotalus durissus terrificus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UMR OCA].
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[[1umr]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Crodu Crodu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UMR OCA].
==Reference==
==Reference==
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<ref group="xtra">PMID:014521935</ref><references group="xtra"/>
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<ref group="xtra">PMID:014521935</ref><references group="xtra"/><references/>
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[[Category: Crotalus durissus terrificus]]
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[[Category: Crodu]]
[[Category: Arni, R K.]]
[[Category: Arni, R K.]]
[[Category: Cintra, A C.O.]]
[[Category: Cintra, A C.O.]]
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[[Category: Activator]]
[[Category: Activator]]
[[Category: C-type lectin]]
[[Category: C-type lectin]]
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[[Category: Crotalus durissus terrificus]]
 
[[Category: Lectin]]
[[Category: Lectin]]
[[Category: Platelet]]
[[Category: Platelet]]
[[Category: Snake venom]]
[[Category: Snake venom]]
[[Category: Sugar-binding protein]]
[[Category: Sugar-binding protein]]

Revision as of 11:56, 20 November 2013

Template:STRUCTURE 1umr

Contents

Crystal structure of the platelet activator convulxin, a disulfide linked a4b4 cyclic tetramer from the venom of Crotalus durissus terrificus

Template:ABSTRACT PUBMED 14521935

Function

[SLA_CRODU] Snake venom lectin that activates platelets by binding to the platelet collagen receptor glycoprotein VI (GP6) (PubMed:9153205). The indirect activation of integrin alpha-IIb/beta-3 (ITGA2B/ITGB3) also induced by the toxin is upstream the cytoskeletal translocation of GPIb, FcRgamma (FCER1G) and 14-3-3zeta (YWHAZ)(PubMed:16102113).[1] [2] [SLB_CRODU] Snake venom lectin that activates platelets by binding to the platelet collagen receptor glycoprotein VI (GP6) (PubMed:9153205). The indirect activation of integrin alpha-IIb/beta-3 (ITGA2B/ITGB3) also induced by the toxin is upstream the cytoskeletal translocation of GPIb, FcRgamma (FCER1G) and 14-3-3zeta (YWHAZ)(PubMed:16102113).[3] [4]

About this Structure

1umr is a 4 chain structure with sequence from Crodu. Full crystallographic information is available from OCA.

Reference

  • Murakami MT, Zela SP, Gava LM, Michelan-Duarte S, Cintra AC, Arni RK. Crystal structure of the platelet activator convulxin, a disulfide-linked alpha4beta4 cyclic tetramer from the venom of Crotalus durissus terrificus. Biochem Biophys Res Commun. 2003 Oct 17;310(2):478-82. PMID:14521935
  1. ↑ Polgar J, Clemetson JM, Kehrel BE, Wiedemann M, Magnenat EM, Wells TN, Clemetson KJ. Platelet activation and signal transduction by convulxin, a C-type lectin from Crotalus durissus terrificus (tropical rattlesnake) venom via the p62/GPVI collagen receptor. J Biol Chem. 1997 May 23;272(21):13576-83. PMID:9153205
  2. ↑ Lu Q, Clemetson JM, Clemetson KJ. Translocation of GPIb and Fc receptor gamma-chain to cytoskeleton in mucetin-activated platelets. J Thromb Haemost. 2005 Sep;3(9):2065-76. PMID:16102113 doi:http://dx.doi.org/10.1111/j.1538-7836.2005.01481.x
  3. ↑ Polgar J, Clemetson JM, Kehrel BE, Wiedemann M, Magnenat EM, Wells TN, Clemetson KJ. Platelet activation and signal transduction by convulxin, a C-type lectin from Crotalus durissus terrificus (tropical rattlesnake) venom via the p62/GPVI collagen receptor. J Biol Chem. 1997 May 23;272(21):13576-83. PMID:9153205
  4. ↑ Lu Q, Clemetson JM, Clemetson KJ. Translocation of GPIb and Fc receptor gamma-chain to cytoskeleton in mucetin-activated platelets. J Thromb Haemost. 2005 Sep;3(9):2065-76. PMID:16102113 doi:http://dx.doi.org/10.1111/j.1538-7836.2005.01481.x

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