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1umr
From Proteopedia
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| - | [[Image:1umr.png|left|200px]] | ||
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{{STRUCTURE_1umr| PDB=1umr | SCENE= }} | {{STRUCTURE_1umr| PDB=1umr | SCENE= }} | ||
| + | ===Crystal structure of the platelet activator convulxin, a disulfide linked a4b4 cyclic tetramer from the venom of Crotalus durissus terrificus=== | ||
| + | {{ABSTRACT_PUBMED_14521935}} | ||
| - | == | + | ==Function== |
| - | + | [[http://www.uniprot.org/uniprot/SLA_CRODU SLA_CRODU]] Snake venom lectin that activates platelets by binding to the platelet collagen receptor glycoprotein VI (GP6) (PubMed:9153205). The indirect activation of integrin alpha-IIb/beta-3 (ITGA2B/ITGB3) also induced by the toxin is upstream the cytoskeletal translocation of GPIb, FcRgamma (FCER1G) and 14-3-3zeta (YWHAZ)(PubMed:16102113).<ref>PMID:9153205</ref> <ref>PMID:16102113</ref> [[http://www.uniprot.org/uniprot/SLB_CRODU SLB_CRODU]] Snake venom lectin that activates platelets by binding to the platelet collagen receptor glycoprotein VI (GP6) (PubMed:9153205). The indirect activation of integrin alpha-IIb/beta-3 (ITGA2B/ITGB3) also induced by the toxin is upstream the cytoskeletal translocation of GPIb, FcRgamma (FCER1G) and 14-3-3zeta (YWHAZ)(PubMed:16102113).<ref>PMID:9153205</ref> <ref>PMID:16102113</ref> | |
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==About this Structure== | ==About this Structure== | ||
| - | [[1umr]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | [[1umr]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Crodu Crodu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UMR OCA]. |
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:014521935</ref><references group="xtra"/> | + | <ref group="xtra">PMID:014521935</ref><references group="xtra"/><references/> |
| - | [[Category: | + | [[Category: Crodu]] |
[[Category: Arni, R K.]] | [[Category: Arni, R K.]] | ||
[[Category: Cintra, A C.O.]] | [[Category: Cintra, A C.O.]] | ||
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[[Category: Activator]] | [[Category: Activator]] | ||
[[Category: C-type lectin]] | [[Category: C-type lectin]] | ||
| - | [[Category: Crotalus durissus terrificus]] | ||
[[Category: Lectin]] | [[Category: Lectin]] | ||
[[Category: Platelet]] | [[Category: Platelet]] | ||
[[Category: Snake venom]] | [[Category: Snake venom]] | ||
[[Category: Sugar-binding protein]] | [[Category: Sugar-binding protein]] | ||
Revision as of 11:56, 20 November 2013
Contents |
Crystal structure of the platelet activator convulxin, a disulfide linked a4b4 cyclic tetramer from the venom of Crotalus durissus terrificus
Template:ABSTRACT PUBMED 14521935
Function
[SLA_CRODU] Snake venom lectin that activates platelets by binding to the platelet collagen receptor glycoprotein VI (GP6) (PubMed:9153205). The indirect activation of integrin alpha-IIb/beta-3 (ITGA2B/ITGB3) also induced by the toxin is upstream the cytoskeletal translocation of GPIb, FcRgamma (FCER1G) and 14-3-3zeta (YWHAZ)(PubMed:16102113).[1] [2] [SLB_CRODU] Snake venom lectin that activates platelets by binding to the platelet collagen receptor glycoprotein VI (GP6) (PubMed:9153205). The indirect activation of integrin alpha-IIb/beta-3 (ITGA2B/ITGB3) also induced by the toxin is upstream the cytoskeletal translocation of GPIb, FcRgamma (FCER1G) and 14-3-3zeta (YWHAZ)(PubMed:16102113).[3] [4]
About this Structure
1umr is a 4 chain structure with sequence from Crodu. Full crystallographic information is available from OCA.
Reference
- Murakami MT, Zela SP, Gava LM, Michelan-Duarte S, Cintra AC, Arni RK. Crystal structure of the platelet activator convulxin, a disulfide-linked alpha4beta4 cyclic tetramer from the venom of Crotalus durissus terrificus. Biochem Biophys Res Commun. 2003 Oct 17;310(2):478-82. PMID:14521935
- ↑ Polgar J, Clemetson JM, Kehrel BE, Wiedemann M, Magnenat EM, Wells TN, Clemetson KJ. Platelet activation and signal transduction by convulxin, a C-type lectin from Crotalus durissus terrificus (tropical rattlesnake) venom via the p62/GPVI collagen receptor. J Biol Chem. 1997 May 23;272(21):13576-83. PMID:9153205
- ↑ Lu Q, Clemetson JM, Clemetson KJ. Translocation of GPIb and Fc receptor gamma-chain to cytoskeleton in mucetin-activated platelets. J Thromb Haemost. 2005 Sep;3(9):2065-76. PMID:16102113 doi:http://dx.doi.org/10.1111/j.1538-7836.2005.01481.x
- ↑ Polgar J, Clemetson JM, Kehrel BE, Wiedemann M, Magnenat EM, Wells TN, Clemetson KJ. Platelet activation and signal transduction by convulxin, a C-type lectin from Crotalus durissus terrificus (tropical rattlesnake) venom via the p62/GPVI collagen receptor. J Biol Chem. 1997 May 23;272(21):13576-83. PMID:9153205
- ↑ Lu Q, Clemetson JM, Clemetson KJ. Translocation of GPIb and Fc receptor gamma-chain to cytoskeleton in mucetin-activated platelets. J Thromb Haemost. 2005 Sep;3(9):2065-76. PMID:16102113 doi:http://dx.doi.org/10.1111/j.1538-7836.2005.01481.x
