4c0f

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==About this Structure==
==About this Structure==
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[[4c0f]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C0F OCA].
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[[4c0f]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C0F OCA].
==Reference==
==Reference==
<ref group="xtra">PMID:024121232</ref><references group="xtra"/><references/>
<ref group="xtra">PMID:024121232</ref><references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Human]]
[[Category: Boland, A.]]
[[Category: Boland, A.]]
[[Category: Chen, Y.]]
[[Category: Chen, Y.]]

Revision as of 12:02, 20 November 2013

Template:STRUCTURE 4c0f

Contents

Structure of the NOT-box domain of human CNOT2

Template:ABSTRACT PUBMED 24121232

Function

[CNOT2_HUMAN] Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specificly involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of emryonic stem (ES) cell identity.[1] [2] [3] [4]

About this Structure

4c0f is a 4 chain structure with sequence from Human. Full crystallographic information is available from OCA.

Reference

  • Boland A, Chen Y, Raisch T, Jonas S, Kuzuoglu-Ozturk D, Wohlbold L, Weichenrieder O, Izaurralde E. Structure and assembly of the NOT module of the human CCR4-NOT complex. Nat Struct Mol Biol. 2013 Oct 13. doi: 10.1038/nsmb.2681. PMID:24121232 doi:http://dx.doi.org/10.1038/nsmb.2681
  1. ↑ Zwartjes CG, Jayne S, van den Berg DL, Timmers HT. Repression of promoter activity by CNOT2, a subunit of the transcription regulatory Ccr4-not complex. J Biol Chem. 2004 Mar 19;279(12):10848-54. Epub 2004 Jan 5. PMID:14707134 doi:http://dx.doi.org/10.1074/jbc.M311747200
  2. ↑ Jayne S, Zwartjes CG, van Schaik FM, Timmers HT. Involvement of the SMRT/NCoR-HDAC3 complex in transcriptional repression by the CNOT2 subunit of the human Ccr4-Not complex. Biochem J. 2006 Sep 15;398(3):461-7. PMID:16712523 doi:http://dx.doi.org/10.1042/BJ20060406
  3. ↑ Ito K, Inoue T, Yokoyama K, Morita M, Suzuki T, Yamamoto T. CNOT2 depletion disrupts and inhibits the CCR4-NOT deadenylase complex and induces apoptotic cell death. Genes Cells. 2011 Apr;16(4):368-79. doi: 10.1111/j.1365-2443.2011.01492.x. Epub, 2011 Feb 8. PMID:21299754 doi:http://dx.doi.org/10.1111/j.1365-2443.2011.01492.x
  4. ↑ Zheng X, Dumitru R, Lackford BL, Freudenberg JM, Singh AP, Archer TK, Jothi R, Hu G. Cnot1, Cnot2, and Cnot3 maintain mouse and human ESC identity and inhibit extraembryonic differentiation. Stem Cells. 2012 May;30(5):910-22. doi: 10.1002/stem.1070. PMID:22367759 doi:http://dx.doi.org/10.1002/stem.1070

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