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1xei
From Proteopedia
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Revision as of 14:27, 30 October 2007
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THE CRYSTAL STRUCTURES OF LYSOZYME AT VERY LOW LEVELS OF HYDRATION
Overview
Earlier studies involving water-mediated transformations in lysozyme and, ribonuclease A have shown that the overall movements in the protein, molecule consequent to the reduction in the amount of surrounding water, are similar to those that occur during enzyme action, thus highlighting, the relationship among hydration, plasticity, and action of these enzymes., Monoclinic lysozyme retains its crystallinity even when the level of, hydration is reduced further below that necessary for activity (about 0.2, gram of water per gram of protein). In order to gain insights into the, role of water in the stability and the plasticity of the protein molecule, and the geometrical basis for the loss of activity that accompanies, dehydration, the crystal structures of monoclinic lysozyme with solvent, ... [(full description)]
About this Structure
1XEI is a [Single protein] structure of sequence from [Gallus gallus]. Active as [Lysozyme], with EC number [3.2.1.17]. Structure known Active Site: CAT. Full crystallographic information is available from [OCA].
Reference
Role of water in plasticity, stability, and action of proteins: the crystal structures of lysozyme at very low levels of hydration., Nagendra HG, Sukumar N, Vijayan M, Proteins. 1998 Aug 1;32(2):229-40. PMID:9714162
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