3iig

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[[Image:3iig.png|left|200px]]
 
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{{STRUCTURE_3iig| PDB=3iig | SCENE= }}
{{STRUCTURE_3iig| PDB=3iig | SCENE= }}
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===Crystal structure of mouse Bcl-xl mutant (F105A) at pH 5.0===
===Crystal structure of mouse Bcl-xl mutant (F105A) at pH 5.0===
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{{ABSTRACT_PUBMED_20206602}}
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{{ABSTRACT_PUBMED_20206602}}
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==Function==
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[[http://www.uniprot.org/uniprot/B2CL1_MOUSE B2CL1_MOUSE]] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:9390687</ref> Isoform Bcl-X(S) promotes apoptosis (By similarity).<ref>PMID:9390687</ref>
==About this Structure==
==About this Structure==
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[[3iig]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IIG OCA].
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[[3iig]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IIG OCA].
==See Also==
==See Also==
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==Reference==
==Reference==
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<ref group="xtra">PMID:020206602</ref><references group="xtra"/>
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<ref group="xtra">PMID:020206602</ref><references group="xtra"/><references/>
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[[Category: Mus musculus]]
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[[Category: Lk3 transgenic mice]]
[[Category: Hwang, K Y.]]
[[Category: Hwang, K Y.]]
[[Category: Priyadarshi, A.]]
[[Category: Priyadarshi, A.]]

Revision as of 12:08, 20 November 2013

Template:STRUCTURE 3iig

Contents

Crystal structure of mouse Bcl-xl mutant (F105A) at pH 5.0

Template:ABSTRACT PUBMED 20206602

Function

[B2CL1_MOUSE] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.[1] Isoform Bcl-X(S) promotes apoptosis (By similarity).[2]

About this Structure

3iig is a 1 chain structure with sequence from Lk3 transgenic mice. Full crystallographic information is available from OCA.

See Also

Reference

  • Priyadarshi A, Roy A, Kim KS, Kim EE, Hwang KY. Structural insights into mouse anti-apoptotic Bcl-xl reveal affinity for Beclin 1 and gossypol. Biochem Biophys Res Commun. 2010 Apr 9;394(3):515-21. Epub 2010 Mar 4. PMID:20206602 doi:10.1016/j.bbrc.2010.03.002
  1. ↑ Yang XF, Weber GF, Cantor H. A novel Bcl-x isoform connected to the T cell receptor regulates apoptosis in T cells. Immunity. 1997 Nov;7(5):629-39. PMID:9390687
  2. ↑ Yang XF, Weber GF, Cantor H. A novel Bcl-x isoform connected to the T cell receptor regulates apoptosis in T cells. Immunity. 1997 Nov;7(5):629-39. PMID:9390687

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