4f7b

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{{STRUCTURE_4f7b| PDB=4f7b | SCENE= }}
{{STRUCTURE_4f7b| PDB=4f7b | SCENE= }}
===Structure of the lysosomal domain of limp-2===
===Structure of the lysosomal domain of limp-2===
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{{ABSTRACT_PUBMED_24162852}}
==Disease==
==Disease==
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==About this Structure==
==About this Structure==
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[[4f7b]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F7B OCA].
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[[4f7b]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F7B OCA].
==Reference==
==Reference==
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<references group="xtra"/><references/>
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<ref group="xtra">PMID:024162852</ref><references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Human]]
[[Category: Arrowsmith, C H.]]
[[Category: Arrowsmith, C H.]]
[[Category: Bountra, C.]]
[[Category: Bountra, C.]]

Revision as of 12:14, 20 November 2013

Template:STRUCTURE 4f7b

Contents

Structure of the lysosomal domain of limp-2

Template:ABSTRACT PUBMED 24162852

Disease

[SCRB2_HUMAN] Unverricht-Lundborg disease;Gaucher disease type 1;Action myoclonus - renal failure syndrome. The disease is caused by mutations affecting the gene represented in this entry. Genetic variants in SCARB2 can act as modifier of the phenotypic expression and severity of Gaucher disease.

Function

[SCRB2_HUMAN] Acts as a lysosomal receptor for glucosylceramidase (GBA) targeting.[1]

About this Structure

4f7b is a 6 chain structure with sequence from Human. Full crystallographic information is available from OCA.

Reference

  • Neculai D, Schwake M, Ravichandran M, Zunke F, Collins RF, Peters J, Neculai M, Plumb J, Loppnau P, Pizarro JC, Seitova A, Trimble WS, Saftig P, Grinstein S, Dhe-Paganon S. Structure of LIMP-2 provides functional insights with implications for SR-BI and CD36. Nature. 2013 Oct 27. doi: 10.1038/nature12684. PMID:24162852 doi:http://dx.doi.org/10.1038/nature12684
  1. ↑ Reczek D, Schwake M, Schroder J, Hughes H, Blanz J, Jin X, Brondyk W, Van Patten S, Edmunds T, Saftig P. LIMP-2 is a receptor for lysosomal mannose-6-phosphate-independent targeting of beta-glucocerebrosidase. Cell. 2007 Nov 16;131(4):770-83. PMID:18022370 doi:http://dx.doi.org/10.1016/j.cell.2007.10.018

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