2w0s

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[[Image:2w0s.png|left|200px]]
 
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{{STRUCTURE_2w0s| PDB=2w0s | SCENE= }}
{{STRUCTURE_2w0s| PDB=2w0s | SCENE= }}
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===Crystal structure of vaccinia virus thymidylate kinase bound to brivudin-5'-monophosphate===
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{{ABSTRACT_PUBMED_18971333}}
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===CRYSTAL STRUCTURE OF VACCINIA VIRUS THYMIDYLATE KINASE BOUND TO BRIVUDIN-5'-MONOPHOSPHATE===
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==Function==
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[[http://www.uniprot.org/uniprot/KTHY_VACCC KTHY_VACCC]] Poxvirus TMP kinase is able to phosphorylate dTMP, dUMP and also dGMP from any purine and pyrimidine nucleoside triphosphate. The large substrate specificity is explained by the presence of a canal connecting the edge of the dimer interface to the TMP base binding pocket, canal not found in the human homolog (By similarity).
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{{ABSTRACT_PUBMED_18971333}}
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==About this Structure==
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[[2w0s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Vaccc Vaccc]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W0S OCA].
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==About this Structure==
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==See Also==
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[[2w0s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Vaccinia_virus_copenhagen Vaccinia virus copenhagen]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W0S OCA].
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*[[Thymidylate kinase|Thymidylate kinase]]
==Reference==
==Reference==
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<ref group="xtra">PMID:018971333</ref><references group="xtra"/>
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<ref group="xtra">PMID:018971333</ref><references group="xtra"/><references/>
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[[Category: Vaccinia virus copenhagen]]
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[[Category: Vaccc]]
[[Category: DTMP kinase]]
[[Category: DTMP kinase]]
[[Category: Agrofoglio, L A.]]
[[Category: Agrofoglio, L A.]]

Revision as of 12:14, 20 November 2013

Template:STRUCTURE 2w0s

Contents

Crystal structure of vaccinia virus thymidylate kinase bound to brivudin-5'-monophosphate

Template:ABSTRACT PUBMED 18971333

Function

[KTHY_VACCC] Poxvirus TMP kinase is able to phosphorylate dTMP, dUMP and also dGMP from any purine and pyrimidine nucleoside triphosphate. The large substrate specificity is explained by the presence of a canal connecting the edge of the dimer interface to the TMP base binding pocket, canal not found in the human homolog (By similarity).

About this Structure

2w0s is a 2 chain structure with sequence from Vaccc. Full crystallographic information is available from OCA.

See Also

Reference

  • Caillat C, Topalis D, Agrofoglio LA, Pochet S, Balzarini J, Deville-Bonne D, Meyer P. Crystal structure of poxvirus thymidylate kinase: an unexpected dimerization has implications for antiviral therapy. Proc Natl Acad Sci U S A. 2008 Nov 4;105(44):16900-5. Epub 2008 Oct 29. PMID:18971333

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