2ygd
From Proteopedia
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{{STRUCTURE_2ygd| PDB=2ygd | SCENE= }} | {{STRUCTURE_2ygd| PDB=2ygd | SCENE= }} | ||
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===Molecular architectures of the 24meric eye lens chaperone alphaB- crystallin elucidated by a triple hybrid approach=== | ===Molecular architectures of the 24meric eye lens chaperone alphaB- crystallin elucidated by a triple hybrid approach=== | ||
| + | {{ABSTRACT_PUBMED_22143763}} | ||
| + | ==Disease== | ||
| + | [[http://www.uniprot.org/uniprot/CRYAB_HUMAN CRYAB_HUMAN]] Posterior polar cataract;Alpha-crystallinopathy;Zonular cataract;Familial isolated dilated cardiomyopathy;Fatal infantile hypertonic myofibrillar myopathy. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. | ||
| - | + | ==Function== | |
| - | + | [[http://www.uniprot.org/uniprot/CRYAB_HUMAN CRYAB_HUMAN]] May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. | |
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==About this Structure== | ==About this Structure== | ||
| - | [[2ygd]] is a 24 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | [[2ygd]] is a 24 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YGD OCA]. |
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:022143763</ref><references group="xtra"/> | + | <ref group="xtra">PMID:022143763</ref><references group="xtra"/><references/> |
| - | [[Category: | + | [[Category: Human]] |
[[Category: Braun, N.]] | [[Category: Braun, N.]] | ||
[[Category: Buchner, J.]] | [[Category: Buchner, J.]] | ||
Revision as of 12:25, 20 November 2013
Contents |
Molecular architectures of the 24meric eye lens chaperone alphaB- crystallin elucidated by a triple hybrid approach
Template:ABSTRACT PUBMED 22143763
Disease
[CRYAB_HUMAN] Posterior polar cataract;Alpha-crystallinopathy;Zonular cataract;Familial isolated dilated cardiomyopathy;Fatal infantile hypertonic myofibrillar myopathy. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
Function
[CRYAB_HUMAN] May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.
About this Structure
2ygd is a 24 chain structure with sequence from Human. Full crystallographic information is available from OCA.
Reference
- Braun N, Zacharias M, Peschek J, Kastenmuller A, Zou J, Hanzlik M, Haslbeck M, Rappsilber J, Buchner J, Weinkauf S. Multiple molecular architectures of the eye lens chaperone alphaB-crystallin elucidated by a triple hybrid approach. Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20491-6. Epub 2011 Dec 5. PMID:22143763 doi:10.1073/pnas.1111014108
