4n5t

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Revision as of 07:36, 16 October 2013 (edit) OCA (Talk | contribs) m (Protected "4n5t" [edit=sysop:move=sysop]) ← Previous diff		Revision as of 13:27, 20 November 2013 (edit) (undo) OCA (Talk | contribs) Next diff →
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-	'''Unreleased structure'''	+	{{STRUCTURE_4n5t| PDB=4n5t | SCENE= }}
		+	===The 1.7A Crystal Structure of MDMX with a Stapled Peptide, ATSP-7041===
		+	{{ABSTRACT_PUBMED_23946421}}
-	The entry 4n5t is ON HOLD	+	==Function==
		+	[[http://www.uniprot.org/uniprot/MDM4_DANRE MDM4_DANRE]] Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain (By similarity).
-	Authors: Graves, B.J., Lukacs, C., Janson, C.A.	+	==About this Structure==
		+	[[4n5t]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N5T OCA].
-	Description: The 1.7A Crystal Structure of MDMX with a Stapled Peptide, ATSP-7041	+	==Reference==
		+	<ref group="xtra">PMID:023946421</ref><references group="xtra"/><references/>
		+	[[Category: Graves, B J.]]
		+	[[Category: Janson, C A.]]
		+	[[Category: Lukacs, C.]]
		+	[[Category: Apoptosis]]
		+	[[Category: Cell cycle]]
		+	[[Category: Cell cycle-cell cycle inhibitor complex]]
		+	[[Category: Mdm4]]
		+	[[Category: Nucleus]]
		+	[[Category: P53]]
		+	[[Category: P53 antagonist]]

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Revision as of 13:27, 20 November 2013

Template:STRUCTURE 4n5t

Contents 1 The 1.7A Crystal Structure of MDMX with a Stapled Peptide, ATSP-7041 2 Function 3 About this Structure 4 Reference

The 1.7A Crystal Structure of MDMX with a Stapled Peptide, ATSP-7041

Template:ABSTRACT PUBMED 23946421

Function

[MDM4_DANRE] Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain (By similarity).

About this Structure

4n5t is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

• Chang YS, Graves B, Guerlavais V, Tovar C, Packman K, To KH, Olson KA, Kesavan K, Gangurde P, Mukherjee A, Baker T, Darlak K, Elkin C, Filipovic Z, Qureshi FZ, Cai H, Berry P, Feyfant E, Shi XE, Horstick J, Annis DA, Manning AM, Fotouhi N, Nash H, Vassilev LT, Sawyer TK. Stapled alpha-helical peptide drug development: a potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy. Proc Natl Acad Sci U S A. 2013 Sep 3;110(36):E3445-54. doi:, 10.1073/pnas.1303002110. Epub 2013 Aug 14. PMID:23946421 doi:http://dx.doi.org/10.1073/pnas.1303002110