2qdf
From Proteopedia
(New page: 200px<br /><applet load="2qdf" size="350" color="white" frame="true" align="right" spinBox="true" caption="2qdf, resolution 2.200Å" /> '''Structure of N-term...) |
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==Overview== | ==Overview== | ||
| - | Integral beta-barrel proteins are found in the outer membranes of | + | Integral beta-barrel proteins are found in the outer membranes of mitochondria, chloroplasts, and Gram-negative bacteria. The machine that assembles these proteins contains an integral membrane protein, called YaeT in Escherichia coli, which has one or more polypeptide transport-associated (POTRA) domains. The crystal structure of a periplasmic fragment of YaeT reveals the POTRA domain fold and suggests a model for how POTRA domains can bind different peptide sequences, as required for a machine that handles numerous beta-barrel protein precursors. Analysis of POTRA domain deletions shows which are essential and provides a view of the spatial organization of this assembly machine. |
==About this Structure== | ==About this Structure== | ||
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[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Harrison, S | + | [[Category: Harrison, S C.]] |
[[Category: Kahne, D.]] | [[Category: Kahne, D.]] | ||
[[Category: Kim, S.]] | [[Category: Kim, S.]] | ||
| - | [[Category: Malinverni, J | + | [[Category: Malinverni, J C.]] |
| - | [[Category: Silhavy, T | + | [[Category: Silhavy, T J.]] |
[[Category: Sliz, P.]] | [[Category: Sliz, P.]] | ||
[[Category: MG]] | [[Category: MG]] | ||
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[[Category: protein transport]] | [[Category: protein transport]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:38:23 2008'' |
Revision as of 16:38, 21 February 2008
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Structure of N-terminal domain of E. Coli YaeT
Overview
Integral beta-barrel proteins are found in the outer membranes of mitochondria, chloroplasts, and Gram-negative bacteria. The machine that assembles these proteins contains an integral membrane protein, called YaeT in Escherichia coli, which has one or more polypeptide transport-associated (POTRA) domains. The crystal structure of a periplasmic fragment of YaeT reveals the POTRA domain fold and suggests a model for how POTRA domains can bind different peptide sequences, as required for a machine that handles numerous beta-barrel protein precursors. Analysis of POTRA domain deletions shows which are essential and provides a view of the spatial organization of this assembly machine.
About this Structure
2QDF is a Single protein structure of sequence from Escherichia coli with as ligand. Full crystallographic information is available from OCA.
Reference
Structure and function of an essential component of the outer membrane protein assembly machine., Kim S, Malinverni JC, Sliz P, Silhavy TJ, Harrison SC, Kahne D, Science. 2007 Aug 17;317(5840):961-4. PMID:17702946
Page seeded by OCA on Thu Feb 21 18:38:23 2008
