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4bmj
From Proteopedia
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| - | + | {{STRUCTURE_4bmj| PDB=4bmj | SCENE= }} | |
| + | ===Structure of the UBZ1and2 tandem of the ubiquitin-binding adaptor protein TAX1BP1=== | ||
| - | + | ==Function== | |
| + | [[http://www.uniprot.org/uniprot/TAXB1_HUMAN TAXB1_HUMAN]] Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade.<ref>PMID:10435631</ref> <ref>PMID:10920205</ref> | ||
| - | + | ==About this Structure== | |
| + | [[4bmj]] is a 11 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BMJ OCA]. | ||
| - | + | ==Reference== | |
| + | <references group="xtra"/><references/> | ||
| + | [[Category: Bravo, J.]] | ||
| + | [[Category: Buts, L.]] | ||
| + | [[Category: Ceregido, M A.]] | ||
| + | [[Category: Nuland, N A.J van.]] | ||
| + | [[Category: Rivera, J.]] | ||
| + | [[Category: Spinola-Amilibia, M.]] | ||
| + | [[Category: Apoptosis]] | ||
| + | [[Category: Inflammation]] | ||
| + | [[Category: Ubiquitin]] | ||
| + | [[Category: Ubz domain]] | ||
Revision as of 13:37, 20 November 2013
Contents |
Structure of the UBZ1and2 tandem of the ubiquitin-binding adaptor protein TAX1BP1
Function
[TAXB1_HUMAN] Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade.[1] [2]
About this Structure
4bmj is a 11 chain structure. Full crystallographic information is available from OCA.
Reference
- ↑ De Valck D, Jin DY, Heyninck K, Van de Craen M, Contreras R, Fiers W, Jeang KT, Beyaert R. The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases. Oncogene. 1999 Jul 22;18(29):4182-90. PMID:10435631 doi:http://dx.doi.org/10.1038/sj.onc.1202787
- ↑ Ling L, Goeddel DV. T6BP, a TRAF6-interacting protein involved in IL-1 signaling. Proc Natl Acad Sci U S A. 2000 Aug 15;97(17):9567-72. PMID:10920205 doi:http://dx.doi.org/10.1073/pnas.170279097
