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4bmj

From Proteopedia

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'''Unreleased structure'''
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{{STRUCTURE_4bmj| PDB=4bmj | SCENE= }}
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===Structure of the UBZ1and2 tandem of the ubiquitin-binding adaptor protein TAX1BP1===
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The entry 4bmj is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/TAXB1_HUMAN TAXB1_HUMAN]] Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade.<ref>PMID:10435631</ref> <ref>PMID:10920205</ref>
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Authors: Ceregido, M.A., Spinola-Amilibia, M., Buts, L., Rivera, J., Bravo, J., van Nuland, N.A.J.
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==About this Structure==
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[[4bmj]] is a 11 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BMJ OCA].
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Description: Structure of the UBZ1and2 tandem of the ubiquitin-binding adaptor protein TAX1BP1
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Bravo, J.]]
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[[Category: Buts, L.]]
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[[Category: Ceregido, M A.]]
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[[Category: Nuland, N A.J van.]]
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[[Category: Rivera, J.]]
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[[Category: Spinola-Amilibia, M.]]
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[[Category: Apoptosis]]
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[[Category: Inflammation]]
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[[Category: Ubiquitin]]
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[[Category: Ubz domain]]

Revision as of 13:37, 20 November 2013

Template:STRUCTURE 4bmj

Contents

Structure of the UBZ1and2 tandem of the ubiquitin-binding adaptor protein TAX1BP1

Function

[TAXB1_HUMAN] Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade.[1] [2]

About this Structure

4bmj is a 11 chain structure. Full crystallographic information is available from OCA.

Reference

  1. ↑ De Valck D, Jin DY, Heyninck K, Van de Craen M, Contreras R, Fiers W, Jeang KT, Beyaert R. The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases. Oncogene. 1999 Jul 22;18(29):4182-90. PMID:10435631 doi:http://dx.doi.org/10.1038/sj.onc.1202787
  2. ↑ Ling L, Goeddel DV. T6BP, a TRAF6-interacting protein involved in IL-1 signaling. Proc Natl Acad Sci U S A. 2000 Aug 15;97(17):9567-72. PMID:10920205 doi:http://dx.doi.org/10.1073/pnas.170279097

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OCA

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