4c8w

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m (Protected "4c8w" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_4c8w| PDB=4c8w | SCENE= }}
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===Xenopus RSPO2 Fu1-Fu2 crystal form II===
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The entry 4c8w is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/RSPO2_XENTR RSPO2_XENTR]] Activator of the canonical Wnt signaling pathway by acting as a ligand for lgr4-6 receptors. Upon binding to lgr4-6 (lgr4, lgr5 or lgr6), lgr4-6 associate with phosphorylated lrp6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Acts both in the canonical. Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway. Activates neural markers and promotes muscle formation. Overexpression blocks activin, nodal and BMP4 signaling, suggesting that it may negatively regulate the TGF-beta pathway (By similarity).
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Authors: Zebisch, M., Jones, E.Y.
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==About this Structure==
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[[4c8w]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C8W OCA].
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Description: Xenopus RSPO2 Fu1-Fu2 crystal form II
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[[Category: Jones, E Y.]]
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[[Category: Zebisch, M.]]
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[[Category: Lgr4]]
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[[Category: Lgr5]]
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[[Category: Lgr6]]
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[[Category: Membrane]]
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[[Category: R-spo]]
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[[Category: Receptor]]
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[[Category: Rnf43]]
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[[Category: Rspo]]
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[[Category: Rspo1]]
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[[Category: Rspo3]]
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[[Category: Rspo4]]
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[[Category: Signaling protein]]
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[[Category: Signalling]]
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[[Category: Wnt]]
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[[Category: Znrf3]]

Revision as of 13:40, 20 November 2013

Template:STRUCTURE 4c8w

Xenopus RSPO2 Fu1-Fu2 crystal form II

Function

[RSPO2_XENTR] Activator of the canonical Wnt signaling pathway by acting as a ligand for lgr4-6 receptors. Upon binding to lgr4-6 (lgr4, lgr5 or lgr6), lgr4-6 associate with phosphorylated lrp6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Acts both in the canonical. Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway. Activates neural markers and promotes muscle formation. Overexpression blocks activin, nodal and BMP4 signaling, suggesting that it may negatively regulate the TGF-beta pathway (By similarity).

About this Structure

4c8w is a 2 chain structure. Full crystallographic information is available from OCA.

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OCA

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