4hlj

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'''Unreleased structure'''
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{{STRUCTURE_4hlj| PDB=4hlj | SCENE= }}
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===Axon Guidance Receptor===
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The entry 4hlj is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/ROBO1_HUMAN ROBO1_HUMAN]] Receptor for SLIT1 and SLIT2 which are thought to act as molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development. In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex. May be required for lung development.<ref>PMID:10102268</ref>
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Authors: Barak, R., Opatowsky, Y.
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==About this Structure==
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[[4hlj]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HLJ OCA].
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Description: Axon Guidance Receptor
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Barak, R.]]
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[[Category: Opatowsky, Y.]]
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[[Category: Cell adhesion]]

Revision as of 13:41, 20 November 2013

Template:STRUCTURE 4hlj

Contents

Axon Guidance Receptor

Function

[ROBO1_HUMAN] Receptor for SLIT1 and SLIT2 which are thought to act as molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development. In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex. May be required for lung development.[1]

About this Structure

4hlj is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  1. ↑ Brose K, Bland KS, Wang KH, Arnott D, Henzel W, Goodman CS, Tessier-Lavigne M, Kidd T. Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance. Cell. 1999 Mar 19;96(6):795-806. PMID:10102268

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OCA

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