4i0i

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'''Unreleased structure'''
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{{STRUCTURE_4i0i| PDB=4i0i | SCENE= }}
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===SPR and structural analysis yield insight towards mechanism of inhibition of BACE inhibitors===
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The entry 4i0i is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
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Authors: Yao, N., Brecht, E.
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==About this Structure==
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[[4i0i]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I0I OCA].
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Description: SPR and structural analysis yield insight towards mechanism of inhibition of BACE inhibitors
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Memapsin 2]]
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[[Category: Brecht, E.]]
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[[Category: Yao, N.]]
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[[Category: Aspartic protease]]
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[[Category: Bace]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Hydrolysis]]

Revision as of 13:42, 20 November 2013

Template:STRUCTURE 4i0i

Contents

SPR and structural analysis yield insight towards mechanism of inhibition of BACE inhibitors

Function

[BACE1_HUMAN] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.[1] [2]

About this Structure

4i0i is a 3 chain structure. Full crystallographic information is available from OCA.

Reference

  1. ↑ Lin X, Koelsch G, Wu S, Downs D, Dashti A, Tang J. Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein. Proc Natl Acad Sci U S A. 2000 Feb 15;97(4):1456-60. PMID:10677483
  2. ↑ Okada H, Zhang W, Peterhoff C, Hwang JC, Nixon RA, Ryu SH, Kim TW. Proteomic identification of sorting nexin 6 as a negative regulator of BACE1-mediated APP processing. FASEB J. 2010 Aug;24(8):2783-94. doi: 10.1096/fj.09-146357. Epub 2010 Mar 30. PMID:20354142 doi:10.1096/fj.09-146357

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OCA

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