4i18

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'''Unreleased structure'''
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{{STRUCTURE_4i18| PDB=4i18 | SCENE= }}
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===Crystal structure of human prolactin receptor complexed with Fab fragment===
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The entry 4i18 is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/PRLR_HUMAN PRLR_HUMAN]] This is a receptor for the anterior pituitary hormone prolactin (PRL). Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling.<ref>PMID:12580759</ref>
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Authors: Duguid, E.M., Mukherjee, S., Kouadio, J.L.
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==About this Structure==
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[[4i18]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I18 OCA].
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Description: Crystal structure of human prolactin receptor complexed with Fab fragment
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Duguid, E M.]]
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[[Category: Kouadio, J L.]]
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[[Category: Mukherjee, S.]]
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[[Category: Cytokine]]
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[[Category: Immunoglobulin fold]]
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[[Category: Prolactin binding]]
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[[Category: Receptor signaling]]
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[[Category: Signaling protein]]

Revision as of 13:42, 20 November 2013

Template:STRUCTURE 4i18

Contents

Crystal structure of human prolactin receptor complexed with Fab fragment

Function

[PRLR_HUMAN] This is a receptor for the anterior pituitary hormone prolactin (PRL). Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling.[1]

About this Structure

4i18 is a 6 chain structure. Full crystallographic information is available from OCA.

Reference

  1. ↑ Trott JF, Hovey RC, Koduri S, Vonderhaar BK. Alternative splicing to exon 11 of human prolactin receptor gene results in multiple isoforms including a secreted prolactin-binding protein. J Mol Endocrinol. 2003 Feb;30(1):31-47. PMID:12580759

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