4lx1

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'''Unreleased structure'''
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{{STRUCTURE_4lx1| PDB=4lx1 | SCENE= }}
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===Crystal structure of Myo5a globular tail domain===
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The entry 4lx1 is ON HOLD until Paper Publication
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==Disease==
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[[http://www.uniprot.org/uniprot/MYO5A_HUMAN MYO5A_HUMAN]] Griscelli disease type 3;Neuroectodermal melanolysosomal disease;Griscelli disease type 1. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
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Authors: Pylypenko, O., Attanda, W., Coulibaly, D., Gauquelin, C., Houdusse, A.
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==Function==
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[[http://www.uniprot.org/uniprot/MYO5A_HUMAN MYO5A_HUMAN]] Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarization process involved in dendrite formation.<ref>PMID:10448864</ref>
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Description: Crystal structure of Myo5a globular tail domain
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==About this Structure==
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[[4lx1]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LX1 OCA].
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Attanda, W.]]
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[[Category: Coulibaly, D.]]
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[[Category: Gauquelin, C.]]
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[[Category: Houdusse, A.]]
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[[Category: Pylypenko, O.]]
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[[Category: Dil]]
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[[Category: Transport protein]]

Revision as of 13:45, 20 November 2013

Template:STRUCTURE 4lx1

Contents

Crystal structure of Myo5a globular tail domain

Disease

[MYO5A_HUMAN] Griscelli disease type 3;Neuroectodermal melanolysosomal disease;Griscelli disease type 1. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.

Function

[MYO5A_HUMAN] Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarization process involved in dendrite formation.[1]

About this Structure

4lx1 is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  1. ↑ Mehta AD, Rock RS, Rief M, Spudich JA, Mooseker MS, Cheney RE. Myosin-V is a processive actin-based motor. Nature. 1999 Aug 5;400(6744):590-3. PMID:10448864 doi:http://dx.doi.org/10.1038/23072

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OCA

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