Villin
From Proteopedia
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| - | [[Image:2k6n.png|left|thumb|300px|Crystal Strcture of the | + | [[Image:2k6n.png|left|thumb|300px|Crystal Strcture of the human supervillin headpiece, [[2k6n]]]] |
| - | {{STRUCTURE_2k6n| right| PDB=2k6n | SCENE=Villin/Cv/1 |CAPTION=Human | + | {{STRUCTURE_2k6n| right| PDB=2k6n | SCENE=Villin/Cv/1 |CAPTION=Human supervillin headpiece, [[2k6n]] }} |
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| - | [[Villin]] (VIL) is an actin-binding protein. It contains gelsolin-like domains in its N-terminal and a helical headpiece which binds actin<ref>PMID:10480879</ref>. '''Supervillin (SVIL)''' contains numerous gelsolin-like domains in its C-terminal and interacts with actin. '''Advillin (AVIL)''' is another actin-binding protein in the [[gelsolin]] superfamily which is expressed in the peripheral sensory neurons. '''Cytovillin (CVIL) or ezrin''' serves as intermediate between plasma membrane and actin cytoskeleton. images on the left and right correspond to one representative villin structure, ''i.e.'' the human supervillin headpiece ([[2k6n]]). | + | [[Villin]] (VIL) is an actin-binding protein. It contains gelsolin-like domains in its N-terminal and a helical headpiece which binds actin<ref>PMID:10480879</ref>. '''Supervillin (SVIL)''' contains numerous gelsolin-like domains in its C-terminal and interacts with actin. '''Advillin (AVIL)''' is another actin-binding protein in the [[gelsolin]] superfamily which is expressed in the peripheral sensory neurons. '''Cytovillin (CVIL) or ezrin or villin-2''' serves as intermediate between plasma membrane and actin cytoskeleton. images on the left and right correspond to one representative villin structure, ''i.e.'' the human supervillin headpiece ([[2k6n]]). |
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Revision as of 10:10, 24 November 2013
Villin (VIL) is an actin-binding protein. It contains gelsolin-like domains in its N-terminal and a helical headpiece which binds actin[1]. Supervillin (SVIL) contains numerous gelsolin-like domains in its C-terminal and interacts with actin. Advillin (AVIL) is another actin-binding protein in the gelsolin superfamily which is expressed in the peripheral sensory neurons. Cytovillin (CVIL) or ezrin or villin-2 serves as intermediate between plasma membrane and actin cytoskeleton. images on the left and right correspond to one representative villin structure, i.e. the human supervillin headpiece (2k6n).
Contents |
3D Structures of Villin
Updated on 24-November-2013
Supervillin
2k6m, 2k6n – hSVIL headpiece– human – NMR
Villin
3fg7 – hVIL gelsolin domains 4-6
2llf - hVIL gelsolin-like domain 6 - NMR
1unc – hVIL headpiece
3iur - hVIL headpiece H2H3 helices+prolyl endopeptidase – Aeromonas punctata
2rjw, 2rjx, 2rjv, 2rjy, 1yu7, 1yu8 – cVIL headpiece (mutant) – chicken
1yu5, 1qqv - cVIL headpiece
3myc, 3mye, 3nkj, 3mya, 3tjw, 3trv, 3trw, 3try - cVIL headpiece (mutant)
1vii, 2vik, 2vil - cVIL headpiece - NMR
2ppz, 2jm0 - VIL headpiece (mutant) – synthetic – NMR
2f4k, 1wy3, 1wy4, 1yrf, 1yri - VIL fragment (mutant) – synthetic
Advillin
1und – hAVIL headpiece
Cytovillin
1ni2 – hCVIL N terminal
References
- ↑ Friederich E, Vancompernolle K, Louvard D, Vandekerckhove J. Villin function in the organization of the actin cytoskeleton. Correlation of in vivo effects to its biochemical activities in vitro. J Biol Chem. 1999 Sep 17;274(38):26751-60. PMID:10480879
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