4c7b

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{{STRUCTURE_4c7b| PDB=4c7b | SCENE= }}
{{STRUCTURE_4c7b| PDB=4c7b | SCENE= }}
===Complex of human Sirt3 with Bromo-Resveratrol and Fluor-De-Lys peptide===
===Complex of human Sirt3 with Bromo-Resveratrol and Fluor-De-Lys peptide===
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{{ABSTRACT_PUBMED_24211137}}
==Function==
==Function==
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==About this Structure==
==About this Structure==
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[[4c7b]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C7B OCA].
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[[4c7b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C7B OCA].
==Reference==
==Reference==
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<references group="xtra"/><references/>
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<ref group="xtra">PMID:024211137</ref><references group="xtra"/><references/>
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[[Category: Human]]
[[Category: Gertz, M.]]
[[Category: Gertz, M.]]
[[Category: Nguyen, G T.T.]]
[[Category: Nguyen, G T.T.]]

Revision as of 08:25, 27 November 2013

Template:STRUCTURE 4c7b

Contents

Complex of human Sirt3 with Bromo-Resveratrol and Fluor-De-Lys peptide

Template:ABSTRACT PUBMED 24211137

Function

[SIR3_HUMAN] NAD-dependent protein deacetylase. Activates mitochondrial target proteins, including ACSS1, IDH2 and GDH by deacetylating key lysine residues. Contributes to the regulation of the cellular energy metabolism. Important for regulating tissue-specific ATP levels.[1] [2] [3] [4]

About this Structure

4c7b is a 2 chain structure with sequence from Human. Full crystallographic information is available from OCA.

Reference

  • Nguyen GT, Gertz M, Steegborn C. Crystal structures of sirt3 complexes with 4'-bromo-resveratrol reveal binding sites and inhibition mechanism. Chem Biol. 2013 Nov 21;20(11):1375-85. doi: 10.1016/j.chembiol.2013.09.019. Epub , 2013 Nov 7. PMID:24211137 doi:http://dx.doi.org/10.1016/j.chembiol.2013.09.019
  1. ↑ Schwer B, Bunkenborg J, Verdin RO, Andersen JS, Verdin E. Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2. Proc Natl Acad Sci U S A. 2006 Jul 5;103(27):10224-9. Epub 2006 Jun 20. PMID:16788062 doi:10.1073/pnas.0603968103
  2. ↑ Schlicker C, Gertz M, Papatheodorou P, Kachholz B, Becker CF, Steegborn C. Substrates and regulation mechanisms for the human mitochondrial sirtuins Sirt3 and Sirt5. J Mol Biol. 2008 Oct 10;382(3):790-801. doi: 10.1016/j.jmb.2008.07.048. Epub 2008, Jul 25. PMID:18680753 doi:10.1016/j.jmb.2008.07.048
  3. ↑ Ahn BH, Kim HS, Song S, Lee IH, Liu J, Vassilopoulos A, Deng CX, Finkel T. A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis. Proc Natl Acad Sci U S A. 2008 Sep 23;105(38):14447-52. doi:, 10.1073/pnas.0803790105. Epub 2008 Sep 15. PMID:18794531 doi:10.1073/pnas.0803790105
  4. ↑ Jin L, Wei W, Jiang Y, Peng H, Cai J, Mao C, Dai H, Choy W, Bemis JE, Jirousek MR, Milne JC, Westphal CH, Perni RB. Crystal structures of human SIRT3 displaying substrate-induced conformational changes. J Biol Chem. 2009 Sep 4;284(36):24394-405. Epub 2009 Jun 16. PMID:19535340 doi:10.1074/jbc.M109.014928

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