4bmj
From Proteopedia
(Difference between revisions)
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{{STRUCTURE_4bmj| PDB=4bmj | SCENE= }} | {{STRUCTURE_4bmj| PDB=4bmj | SCENE= }} | ||
===Structure of the UBZ1and2 tandem of the ubiquitin-binding adaptor protein TAX1BP1=== | ===Structure of the UBZ1and2 tandem of the ubiquitin-binding adaptor protein TAX1BP1=== | ||
| + | {{ABSTRACT_PUBMED_24239949}} | ||
==Function== | ==Function== | ||
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==About this Structure== | ==About this Structure== | ||
| - | [[4bmj]] is a 11 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BMJ OCA]. | + | [[4bmj]] is a 11 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BMJ OCA]. |
==Reference== | ==Reference== | ||
| - | <references group="xtra"/><references/> | + | <ref group="xtra">PMID:024239949</ref><references group="xtra"/><references/> |
| + | [[Category: Human]] | ||
[[Category: Bravo, J.]] | [[Category: Bravo, J.]] | ||
[[Category: Buts, L.]] | [[Category: Buts, L.]] | ||
Revision as of 08:32, 27 November 2013
Contents |
Structure of the UBZ1and2 tandem of the ubiquitin-binding adaptor protein TAX1BP1
Template:ABSTRACT PUBMED 24239949
Function
[TAXB1_HUMAN] Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade.[1] [2]
About this Structure
4bmj is a 11 chain structure with sequence from Human. Full crystallographic information is available from OCA.
Reference
- Ceregido MA, Spinola Amilibia M, Buts L, Rivera-Torres J, Garcia-Pino A, Bravo J, van Nuland NA. The Structure of TAX1BP1 UBZ1+2 Provides Insight into Target Specificity and Adaptability. J Mol Biol. 2013 Nov 13. pii: S0022-2836(13)00717-1. doi:, 10.1016/j.jmb.2013.11.006. PMID:24239949 doi:http://dx.doi.org/10.1016/j.jmb.2013.11.006
- ↑ De Valck D, Jin DY, Heyninck K, Van de Craen M, Contreras R, Fiers W, Jeang KT, Beyaert R. The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases. Oncogene. 1999 Jul 22;18(29):4182-90. PMID:10435631 doi:http://dx.doi.org/10.1038/sj.onc.1202787
- ↑ Ling L, Goeddel DV. T6BP, a TRAF6-interacting protein involved in IL-1 signaling. Proc Natl Acad Sci U S A. 2000 Aug 15;97(17):9567-72. PMID:10920205 doi:http://dx.doi.org/10.1073/pnas.170279097
