4c12

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===X-ray Crystal Structure of Staphylococcus aureus MurE with UDP-MurNAc- Ala-Glu-Lys and ADP===
===X-ray Crystal Structure of Staphylococcus aureus MurE with UDP-MurNAc- Ala-Glu-Lys and ADP===
{{ABSTRACT_PUBMED_24064214}}
{{ABSTRACT_PUBMED_24064214}}
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==Function==
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[[http://www.uniprot.org/uniprot/MURE_STAA8 MURE_STAA8]] Catalyzes the addition of L-lysine to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Can not use diaminopimelate as substrate. Seems to have a role in beta-lactam antibiotic resistance.<ref>PMID:14114846</ref> <ref>PMID:10498701</ref> <ref>PMID:14996801</ref>
==About this Structure==
==About this Structure==
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[[4c12]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C12 OCA].
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[[4c12]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C12 OCA].
==Reference==
==Reference==
<ref group="xtra">PMID:024064214</ref><references group="xtra"/><references/>
<ref group="xtra">PMID:024064214</ref><references group="xtra"/><references/>
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[[Category: Staphylococcus aureus]]
 
[[Category: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase]]
[[Category: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase]]
[[Category: Barreteau, H.]]
[[Category: Barreteau, H.]]

Revision as of 08:34, 27 November 2013

Template:STRUCTURE 4c12

Contents

X-ray Crystal Structure of Staphylococcus aureus MurE with UDP-MurNAc- Ala-Glu-Lys and ADP

Template:ABSTRACT PUBMED 24064214

Function

[MURE_STAA8] Catalyzes the addition of L-lysine to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Can not use diaminopimelate as substrate. Seems to have a role in beta-lactam antibiotic resistance.[1] [2] [3]

About this Structure

4c12 is a 1 chain structure with sequence from "micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885. Full crystallographic information is available from OCA.

Reference

  • Ruane KM, Lloyd AJ, Fulop V, Dowson CG, Barreteau H, Boniface A, Dementin S, Blanot D, Mengin-Lecreulx D, Gobec S, Dessen A, Roper DI. Specificity Determinants for Lysine Incorporation in Staphylococcus aureus Peptidoglycan as Revealed by the Structure of a MurE Ternary Complex. J Biol Chem. 2013 Sep 24. PMID:24064214 doi:http://dx.doi.org/10.1074/jbc.M113.508135
  1. ↑ ITO E, STROMINGER JL. ENZYMATIC SYNTHESIS OF THE PEPTIDE IN BACTERIAL URIDINE NUCLEOTIDES. III. PURIFICATION AND PROPERTIES OF L-LYSIN-ADDING ENZYME. J Biol Chem. 1964 Jan;239:210-4. PMID:14114846
  2. ↑ Mengin-Lecreulx D, Falla T, Blanot D, van Heijenoort J, Adams DJ, Chopra I. Expression of the Staphylococcus aureus UDP-N-acetylmuramoyl- L-alanyl-D-glutamate:L-lysine ligase in Escherichia coli and effects on peptidoglycan biosynthesis and cell growth. J Bacteriol. 1999 Oct;181(19):5909-14. PMID:10498701
  3. ↑ Gardete S, Ludovice AM, Sobral RG, Filipe SR, de Lencastre H, Tomasz A. Role of murE in the Expression of beta-lactam antibiotic resistance in Staphylococcus aureus. J Bacteriol. 2004 Mar;186(6):1705-13. PMID:14996801

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