4l5b
From Proteopedia
(Difference between revisions)
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==About this Structure== | ==About this Structure== | ||
| - | [[4l5b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | [[4l5b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L5B OCA]. |
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:023947754</ref><references group="xtra"/><references/> | <ref group="xtra">PMID:023947754</ref><references group="xtra"/><references/> | ||
[[Category: Deoxycytidine kinase]] | [[Category: Deoxycytidine kinase]] | ||
| - | [[Category: | + | [[Category: Human]] |
[[Category: Lavie, A.]] | [[Category: Lavie, A.]] | ||
[[Category: Nomme, J.]] | [[Category: Nomme, J.]] | ||
Revision as of 08:40, 27 November 2013
Contents |
Human dCK C4S-S74E mutant in complex with UDP and the DI-43 inhibitor
Template:ABSTRACT PUBMED 23947754
Function
[DCK_HUMAN] Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents.[1] [2]
About this Structure
4l5b is a 2 chain structure with sequence from Human. Full crystallographic information is available from OCA.
Reference
- Murphy JM, Armijo AL, Nomme J, Lee CH, Smith QA, Li Z, Campbell DO, Liao HI, Nathanson DA, Austin WR, Lee JT, Darvish R, Wei L, Wang J, Su Y, Damoiseaux R, Sadeghi S, Phelps ME, Herschman HR, Czernin J, Alexandrova AN, Jung ME, Lavie A, Radu CG. Development of new deoxycytidine kinase inhibitors and noninvasive in vivo evaluation using positron emission tomography. J Med Chem. 2013 Sep 12;56(17):6696-708. doi: 10.1021/jm400457y. Epub 2013 Aug, 15. PMID:23947754 doi:10.1021/jm400457y
- ↑ Sabini E, Hazra S, Ort S, Konrad M, Lavie A. Structural basis for substrate promiscuity of dCK. J Mol Biol. 2008 May 2;378(3):607-21. Epub 2008 Mar 3. PMID:18377927 doi:http://dx.doi.org/10.1016/j.jmb.2008.02.061
- ↑ Hazra S, Ort S, Konrad M, Lavie A. Structural and kinetic characterization of human deoxycytidine kinase variants able to phosphorylate 5-substituted deoxycytidine and thymidine analogues . Biochemistry. 2010 Aug 10;49(31):6784-90. PMID:20614893 doi:10.1021/bi100839e
