4c8w

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{{STRUCTURE_4c8w| PDB=4c8w | SCENE= }}
{{STRUCTURE_4c8w| PDB=4c8w | SCENE= }}
===Xenopus RSPO2 Fu1-Fu2 crystal form II===
===Xenopus RSPO2 Fu1-Fu2 crystal form II===
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{{ABSTRACT_PUBMED_24225776}}
==Function==
==Function==
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==About this Structure==
==About this Structure==
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[[4c8w]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C8W OCA].
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[[4c8w]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Silurana_(xenopus)_tropicalis Silurana (xenopus) tropicalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C8W OCA].
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==Reference==
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<ref group="xtra">PMID:024225776</ref><references group="xtra"/><references/>
[[Category: Jones, E Y.]]
[[Category: Jones, E Y.]]
[[Category: Zebisch, M.]]
[[Category: Zebisch, M.]]

Revision as of 08:42, 27 November 2013

Template:STRUCTURE 4c8w

Contents

Xenopus RSPO2 Fu1-Fu2 crystal form II

Template:ABSTRACT PUBMED 24225776

Function

[RSPO2_XENTR] Activator of the canonical Wnt signaling pathway by acting as a ligand for lgr4-6 receptors. Upon binding to lgr4-6 (lgr4, lgr5 or lgr6), lgr4-6 associate with phosphorylated lrp6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Acts both in the canonical. Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway. Activates neural markers and promotes muscle formation. Overexpression blocks activin, nodal and BMP4 signaling, suggesting that it may negatively regulate the TGF-beta pathway (By similarity).

About this Structure

4c8w is a 2 chain structure with sequence from Silurana (xenopus) tropicalis. Full crystallographic information is available from OCA.

Reference

  • Zebisch M, Xu Y, Krastev C, Macdonald BT, Chen M, Gilbert RJ, He X, Jones EY. Structural and molecular basis of ZNRF3/RNF43 transmembrane ubiquitin ligase inhibition by the Wnt agonist R-spondin. Nat Commun. 2013 Nov 14;4:2787. doi: 10.1038/ncomms3787. PMID:24225776 doi:http://dx.doi.org/10.1038/ncomms3787

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