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4c8t

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{{STRUCTURE_4c8t| PDB=4c8t | SCENE= }}
{{STRUCTURE_4c8t| PDB=4c8t | SCENE= }}
===Xenopus ZNRF3 ectodomain crystal form I===
===Xenopus ZNRF3 ectodomain crystal form I===
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{{ABSTRACT_PUBMED_24225776}}
==Function==
==Function==
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==About this Structure==
==About this Structure==
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[[4c8t]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C8T OCA].
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[[4c8t]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Silurana_(xenopus)_tropicalis Silurana (xenopus) tropicalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C8T OCA].
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==Reference==
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<ref group="xtra">PMID:024225776</ref><references group="xtra"/><references/>
[[Category: Jones, E Y.]]
[[Category: Jones, E Y.]]
[[Category: Zebisch, M.]]
[[Category: Zebisch, M.]]

Revision as of 08:55, 27 November 2013

Template:STRUCTURE 4c8t

Contents

Xenopus ZNRF3 ectodomain crystal form I

Template:ABSTRACT PUBMED 24225776

Function

[ZNRF3_XENTR] E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components (By similarity).

About this Structure

4c8t is a 2 chain structure with sequence from Silurana (xenopus) tropicalis. Full crystallographic information is available from OCA.

Reference

  • Zebisch M, Xu Y, Krastev C, Macdonald BT, Chen M, Gilbert RJ, He X, Jones EY. Structural and molecular basis of ZNRF3/RNF43 transmembrane ubiquitin ligase inhibition by the Wnt agonist R-spondin. Nat Commun. 2013 Nov 14;4:2787. doi: 10.1038/ncomms3787. PMID:24225776 doi:http://dx.doi.org/10.1038/ncomms3787

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