3znl
From Proteopedia
| Line 6: | Line 6: | ||
==About this Structure== | ==About this Structure== | ||
| - | [[3znl]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | [[3znl]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/viet_nam/1194/2004(h5n1)) Influenza a virus (a/viet nam/1194/2004(h5n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZNL OCA]. |
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:024036174</ref><references group="xtra"/><references/> | <ref group="xtra">PMID:024036174</ref><references group="xtra"/><references/> | ||
| - | [[Category: Influenza a virus]] | ||
[[Category: Bovin, N.]] | [[Category: Bovin, N.]] | ||
[[Category: Coombs, P.]] | [[Category: Coombs, P.]] | ||
Revision as of 08:59, 27 November 2013
Contents |
H5 Haemagglutinin in Complex with 6-O-Sulfo-Sialyl-Lewis X (Sulfated Lewis X)
Function
[Q6DQ34_9INFA] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS008980_004_327643]
About this Structure
3znl is a 6 chain structure with sequence from Influenza a virus (a/viet nam/1194/2004(h5n1)). Full crystallographic information is available from OCA.
Reference
- Xiong X, Tuzikov A, Coombs PJ, Martin S, Walker PA, Gamblin SJ, Bovin N, Skehel JJ. Recognition of sulphated and fucosylated receptor sialosides by A/Vietnam/1194/2004 (H5N1) influenza virus. Virus Res. 2013 Sep 10. pii: S0168-1702(13)00286-4. doi:, 10.1016/j.virusres.2013.08.007. PMID:24036174 doi:10.1016/j.virusres.2013.08.007
