4bs5

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m (Protected "4bs5" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_4bs5| PDB=4bs5 | SCENE= }}
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===MOUSE CATHEPSIN S WITH COVALENT LIGAND===
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{{ABSTRACT_PUBMED_24224654}}
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The entry 4bs5 is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/CATS_MOUSE CATS_MOUSE]] Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N.
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Authors: Banner, D.W., Benz, J., Gsell, B., Stihle, M., Ruf, A., Haap, W.
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==About this Structure==
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[[4bs5]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BS5 OCA].
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Description: MOUSE CATHEPSIN S WITH COVALENT LIGAND
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==Reference==
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<ref group="xtra">PMID:024224654</ref><references group="xtra"/><references/>
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[[Category: Cathepsin S]]
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[[Category: Banner, D W.]]
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[[Category: Benz, J.]]
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[[Category: Gsell, B.]]
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[[Category: Haap, W.]]
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[[Category: Ruf, A.]]
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[[Category: Stihle, M.]]
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[[Category: Covalent ligand]]
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[[Category: Cysteine protease]]
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[[Category: Hydrolase]]

Revision as of 10:20, 27 November 2013

Template:STRUCTURE 4bs5

Contents

MOUSE CATHEPSIN S WITH COVALENT LIGAND

Template:ABSTRACT PUBMED 24224654

Function

[CATS_MOUSE] Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N.

About this Structure

4bs5 is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  • Hilpert H, Mauser H, Humm R, Anselm L, Kuehne H, Hartmann G, Gruener S, Banner DW, Benz J, Gsell B, Kuglstatter A, Stihle M, Thoma R, Sanchez RA, Iding H, Wirz B, Haap W. Identification of Potent and Selective Cathepsin S Inhibitors Containing Different Central Cyclic Scaffolds. J Med Chem. 2013 Nov 22. PMID:24224654 doi:http://dx.doi.org/10.1021/jm401528k

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OCA

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