4hhv

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'''Unreleased structure'''
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{{STRUCTURE_4hhv| PDB=4hhv | SCENE= }}
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===Crystal structure of ceramide transfer protein pleckstrin homology domain===
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The entry 4hhv is ON HOLD until Dec 16 2014
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==Function==
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[[http://www.uniprot.org/uniprot/C43BP_HUMAN C43BP_HUMAN]] Shelters ceramides and diacylglycerol lipids inside its START domain and mediates the intracellular trafficking of ceramides and diacylglycerol lipids in a non-vesicular manner.<ref>PMID:14685229</ref> <ref>PMID:17591919</ref> <ref>PMID:18184806</ref> <ref>PMID:20036255</ref>
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Authors: Prashek, J., Truong, T., Yao, X.
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==About this Structure==
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[[4hhv]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HHV OCA].
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Description: Crystal structure of ceramide transfer protein pleckstrin homology domain
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Prashek, J.]]
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[[Category: Truong, T.]]
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[[Category: Yao, X.]]
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[[Category: Binds to phosphatidylinositol 4-phosphate]]
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[[Category: Lipid transport]]
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[[Category: Pleckstrin homology domain fold]]

Revision as of 10:29, 27 November 2013

Template:STRUCTURE 4hhv

Contents

Crystal structure of ceramide transfer protein pleckstrin homology domain

Function

[C43BP_HUMAN] Shelters ceramides and diacylglycerol lipids inside its START domain and mediates the intracellular trafficking of ceramides and diacylglycerol lipids in a non-vesicular manner.[1] [2] [3] [4]

About this Structure

4hhv is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  1. ↑ Hanada K, Kumagai K, Yasuda S, Miura Y, Kawano M, Fukasawa M, Nishijima M. Molecular machinery for non-vesicular trafficking of ceramide. Nature. 2003 Dec 18;426(6968):803-9. PMID:14685229 doi:http://dx.doi.org/10.1038/nature02188
  2. ↑ Fugmann T, Hausser A, Schoffler P, Schmid S, Pfizenmaier K, Olayioye MA. Regulation of secretory transport by protein kinase D-mediated phosphorylation of the ceramide transfer protein. J Cell Biol. 2007 Jul 2;178(1):15-22. Epub 2007 Jun 25. PMID:17591919 doi:http://dx.doi.org/jcb.200612017
  3. ↑ Kudo N, Kumagai K, Tomishige N, Yamaji T, Wakatsuki S, Nishijima M, Hanada K, Kato R. Structural basis for specific lipid recognition by CERT responsible for nonvesicular trafficking of ceramide. Proc Natl Acad Sci U S A. 2008 Jan 15;105(2):488-93. Epub 2008 Jan 9. PMID:18184806
  4. ↑ Kudo N, Kumagai K, Matsubara R, Kobayashi S, Hanada K, Wakatsuki S, Kato R. Crystal structures of the CERT START domain with inhibitors provide insights into the mechanism of ceramide transfer. J Mol Biol. 2010 Feb 19;396(2):245-51. Epub 2009 Dec 28. PMID:20036255 doi:10.1016/j.jmb.2009.12.029

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