4m8o

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'''Unreleased structure'''
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{{STRUCTURE_4m8o| PDB=4m8o | SCENE= }}
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===TERNARY COMPLEX OF DNA POLYMERASE EPSILON WITH AN INCOMING dATP===
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The entry 4m8o is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/DPOE_YEAST DPOE_YEAST]] DNA polymerase epsilon (DNA polymerase II) participates in chromosomal DNA replication. It is required during synthesis of the leading and lagging DNA strands at the replication fork and binds at/or near replication origins and moves along DNA with the replication fork. It has 3'-5' proofreading exonuclease activity that correct errors arising during DNA replication. It is also involved in DNA synthesis during DNA repair.<ref>PMID:12124389</ref>
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Authors: Sauer-Eriksson, A.E., Hogg, M., Osterman, P., Johansson, E.
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==About this Structure==
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[[4m8o]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M8O OCA].
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Description: TERNARY COMPLEX OF DNA POLYMERASE EPSILON WITH AN INCOMING dATP
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==Reference==
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<references group="xtra"/><references/>
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[[Category: DNA-directed DNA polymerase]]
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[[Category: Hogg, M.]]
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[[Category: Johansson, E.]]
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[[Category: Osterman, P.]]
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[[Category: Sauer-Eriksson, A E.]]
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[[Category: Dna polymerase b type]]
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[[Category: Dna replication]]
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[[Category: Dna synthesis]]
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[[Category: Metal-binding]]
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[[Category: Nucleotidyltransferase]]
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[[Category: Protein-dna complex]]
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[[Category: Transferase dna complex]]
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[[Category: Transferase-dna complex]]

Revision as of 10:34, 27 November 2013

Template:STRUCTURE 4m8o

Contents

TERNARY COMPLEX OF DNA POLYMERASE EPSILON WITH AN INCOMING dATP

Function

[DPOE_YEAST] DNA polymerase epsilon (DNA polymerase II) participates in chromosomal DNA replication. It is required during synthesis of the leading and lagging DNA strands at the replication fork and binds at/or near replication origins and moves along DNA with the replication fork. It has 3'-5' proofreading exonuclease activity that correct errors arising during DNA replication. It is also involved in DNA synthesis during DNA repair.[1]

About this Structure

4m8o is a 3 chain structure. Full crystallographic information is available from OCA.

Reference

  1. ↑ Shimizu K, Hashimoto K, Kirchner JM, Nakai W, Nishikawa H, Resnick MA, Sugino A. Fidelity of DNA polymerase epsilon holoenzyme from budding yeast Saccharomyces cerevisiae. J Biol Chem. 2002 Oct 4;277(40):37422-9. Epub 2002 Jul 17. PMID:12124389 doi:http://dx.doi.org/10.1074/jbc.M204476200

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