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From Proteopedia
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| - | '''5-Enolpyruvlyshikimate-3-phosphate synthase''' is an enzyme involved in the shikimate pathway | + | The monomeric enzyme '''5-Enolpyruvlyshikimate-3-phosphate synthase (EPSPS)''' is an enzyme involved in the shikimate pathway found only in plants and microorganisms. The shikimate pathway is essential for the biosynthesis of chorismate, which is the precursor for aromatic amino acids and secondary aromatic metabolites. EPSP synthase uses phosphoenolpyruvate (PEP) to covert shikimate-3-phosphate (S3P) to 5-enolpyruvyl-3-shikimate phosphate, a precursor to majority of the aromatic compounds produced in the cell, including the aromatic amino acids (L-tyrosine, L-phenylalanine, L-tryptophan) that are needed for protein synthesis. |
==EPSP Synthase Structure== | ==EPSP Synthase Structure== | ||
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5-Enolpyruvylshikimate-3-phosphate synthase
The monomeric enzyme 5-Enolpyruvlyshikimate-3-phosphate synthase (EPSPS) is an enzyme involved in the shikimate pathway found only in plants and microorganisms. The shikimate pathway is essential for the biosynthesis of chorismate, which is the precursor for aromatic amino acids and secondary aromatic metabolites. EPSP synthase uses phosphoenolpyruvate (PEP) to covert shikimate-3-phosphate (S3P) to 5-enolpyruvyl-3-shikimate phosphate, a precursor to majority of the aromatic compounds produced in the cell, including the aromatic amino acids (L-tyrosine, L-phenylalanine, L-tryptophan) that are needed for protein synthesis.
EPSP Synthase Structure
EPSP Synthase Mechanism
Implicatons
The implications in studying EPSP synthase involve the fact that this enzyme is not present in humans but is essential for bacteria and apicomplexan parasites. This makes EPSP synthase a selective target for antimicrobial drugs and decreases possible negative impacts of drugs in humans.
