This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
EPSP synthase
From Proteopedia
(Difference between revisions)
(New page: == Structure of EPSP Synthase == <StructureSection load='1eps' size='350' side='right' caption='Structure of EPSP synthase (PDB entry 1eps)' scene=''> 5-enolpyruvylshikimate 3-phospha...) |
|||
| Line 4: | Line 4: | ||
5-enolpyruvylshikimate 3-phosphate (EPSP) synthase is a key enzyme for the biosynthesis of aromatic amino acids in plants and many microbes. Consequently, it is a target for drugs and herbicides. EPSP synthase catalyzes the addition of phosphoenol pyruvate (PEP) to shikimate-3-phosphate, generating 5-enolpyruvylshikimate-3-phosphate, which is a precursor for phenylalanine and tyrosine. | 5-enolpyruvylshikimate 3-phosphate (EPSP) synthase is a key enzyme for the biosynthesis of aromatic amino acids in plants and many microbes. Consequently, it is a target for drugs and herbicides. EPSP synthase catalyzes the addition of phosphoenol pyruvate (PEP) to shikimate-3-phosphate, generating 5-enolpyruvylshikimate-3-phosphate, which is a precursor for phenylalanine and tyrosine. | ||
| - | The enzyme has two domains, with the active site found in the interdomain cleft. There is a substantial structural change upon substrate binding, resulting in a closed formation. Glyphosate (also known as Roundup) occupies the binding site of the second substrate, phosphoenol pyruvate. | + | The enzyme has <scene name='57/570585/Two_domains/1'>two domains</scene>, with the active site found in the interdomain cleft. There is a substantial structural change upon substrate binding, resulting in a <scene name='57/570585/Closed_formation/1'>closed formation</scene>. Glyphosate (also known as Roundup) occupies the binding site of the second substrate, phosphoenol pyruvate. |
| - | </StructureSection | + | </StructureSection> |
| - | + | ||
| - | + | ||
Revision as of 04:15, 2 December 2013
Structure of EPSP Synthase
| |||||||||||
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Alexander Berchansky, Ann Taylor, Joel L. Sussman
