Catabolite control protein
From Proteopedia
(Difference between revisions)
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<StructureSection load='2fep' size='350' side='right' caption='Structure of catabolite control protein (grey) complex with Hpr (khaki) and sulfate (PDB entry [[2fep]])' scene=''> | <StructureSection load='2fep' size='350' side='right' caption='Structure of catabolite control protein (grey) complex with Hpr (khaki) and sulfate (PDB entry [[2fep]])' scene=''> | ||
| - | '''Catabolite control protein''' (CcpA) is a regulator of carbon metabolism in gram-positive bacteria. When high concentrations of glucose-6 phosphate or fructose-1,6-diphosphate are present in the cell, they phosphorylate proteins | + | '''Catabolite control protein''' (CcpA) is a regulator of carbon metabolism in gram-positive bacteria. When high concentrations of glucose-6 phosphate or fructose-1,6-diphosphate are present in the cell, they phosphorylate proteins HPr or Crh which interact with CcpA. The latter binds to DNA operator to modulate transcription. |
==3D structures of catabolite control protein== | ==3D structures of catabolite control protein== | ||
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===CcpA binary complex=== | ===CcpA binary complex=== | ||
| - | [[2oen]] - BmCcpA + phosphocarrier protein | + | [[2oen]] - BmCcpA + phosphocarrier protein HPr <br /> |
| - | [[2fep]] - BsCcpA + phosphocarrier protein | + | [[2fep]] - BsCcpA + phosphocarrier protein HPr – ''Bacillus subtilis''<br /> |
===CcpA ternary complex=== | ===CcpA ternary complex=== | ||
| - | [[1rzr]] – BmCcpA + phosphocarrier protein | + | [[1rzr]] – BmCcpA + phosphocarrier protein HPr + DNA <br /> |
| - | [[2nzu]] - BmCcpA + phosphocarrier protein | + | [[2nzu]] - BmCcpA + phosphocarrier protein HPr + glucose-6-phosphate <br /> |
| - | [[2nzv]] - BmCcpA + phosphocarrier protein | + | [[2nzv]] - BmCcpA + phosphocarrier protein HPr + fructose-1,6-diphosphate <br /> |
[[1zvv]] – BsCcpA + catabolite repression Crh + DNA <br /> | [[1zvv]] – BsCcpA + catabolite repression Crh + DNA <br /> | ||
| - | [[3oqm]], [[3oqn]], [[3oqo]] - BsCcpA + phosphocarrier protein | + | [[3oqm]], [[3oqn]], [[3oqo]] - BsCcpA + phosphocarrier protein HPr + DNA<br /> |
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 07:58, 2 December 2013
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