4mqs

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{{STRUCTURE_4mqs| PDB=4mqs | SCENE= }}
{{STRUCTURE_4mqs| PDB=4mqs | SCENE= }}
===Structure of active human M2 muscarinic acetylcholine receptor bound to the agonist iperoxo===
===Structure of active human M2 muscarinic acetylcholine receptor bound to the agonist iperoxo===
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{{ABSTRACT_PUBMED_24256733}}
==Disease==
==Disease==
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==About this Structure==
==About this Structure==
[[4mqs]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MQS OCA].
[[4mqs]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MQS OCA].
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==Reference==
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<ref group="xtra">PMID:024256733</ref><references group="xtra"/><references/>
[[Category: Christopoulos, A.]]
[[Category: Christopoulos, A.]]
[[Category: Eitel, K.]]
[[Category: Eitel, K.]]

Revision as of 05:56, 4 December 2013

Template:STRUCTURE 4mqs

Contents

Structure of active human M2 muscarinic acetylcholine receptor bound to the agonist iperoxo

Template:ABSTRACT PUBMED 24256733

Disease

[ACM2_HUMAN] Disease susceptibility is associated with variations affecting the gene represented in this entry.

Function

[ACM2_HUMAN] The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition.

About this Structure

4mqs is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  • Kruse AC, Ring AM, Manglik A, Hu J, Hu K, Eitel K, Hubner H, Pardon E, Valant C, Sexton PM, Christopoulos A, Felder CC, Gmeiner P, Steyaert J, Weis WI, Garcia KC, Wess J, Kobilka BK. Activation and allosteric modulation of a muscarinic acetylcholine receptor. Nature. 2013 Nov 20. doi: 10.1038/nature12735. PMID:24256733 doi:http://dx.doi.org/10.1038/nature12735

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