4mqt
From Proteopedia
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{{STRUCTURE_4mqt| PDB=4mqt | SCENE= }} | {{STRUCTURE_4mqt| PDB=4mqt | SCENE= }} | ||
===Structure of active human M2 muscarinic acetylcholine receptor bound to the agonist iperoxo and allosteric modulator LY2119620=== | ===Structure of active human M2 muscarinic acetylcholine receptor bound to the agonist iperoxo and allosteric modulator LY2119620=== | ||
| + | {{ABSTRACT_PUBMED_24256733}} | ||
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
[[4mqt]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MQT OCA]. | [[4mqt]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MQT OCA]. | ||
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| + | ==Reference== | ||
| + | <ref group="xtra">PMID:024256733</ref><references group="xtra"/><references/> | ||
[[Category: Christopoulos, A.]] | [[Category: Christopoulos, A.]] | ||
[[Category: Eitel, K.]] | [[Category: Eitel, K.]] | ||
Revision as of 06:04, 4 December 2013
Contents |
Structure of active human M2 muscarinic acetylcholine receptor bound to the agonist iperoxo and allosteric modulator LY2119620
Template:ABSTRACT PUBMED 24256733
Disease
[ACM2_HUMAN] Disease susceptibility is associated with variations affecting the gene represented in this entry.
Function
[ACM2_HUMAN] The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition.
About this Structure
4mqt is a 2 chain structure. Full crystallographic information is available from OCA.
Reference
- Kruse AC, Ring AM, Manglik A, Hu J, Hu K, Eitel K, Hubner H, Pardon E, Valant C, Sexton PM, Christopoulos A, Felder CC, Gmeiner P, Steyaert J, Weis WI, Garcia KC, Wess J, Kobilka BK. Activation and allosteric modulation of a muscarinic acetylcholine receptor. Nature. 2013 Nov 20. doi: 10.1038/nature12735. PMID:24256733 doi:http://dx.doi.org/10.1038/nature12735
Categories: Christopoulos, A. | Eitel, K. | Felder, C C. | Garcia, K C. | Gmeiner, P. | Hu, J. | Hu, K. | Huebner, H. | Kobilka, B K. | Kruse, A C. | Manglik, A. | Pardon, E. | Ring, A M. | Sexton, P M. | Steyaert, J. | Valant, C. | Weis, W I. | Wess, J. | Allosteric modulation | G protein-coupled receptor | Muscarinic acetylcholine receptor | Signaling protein
