Beta-Hexosaminidase
From Proteopedia
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=== {{Nowrap|Structure of Human β-Hexosaminidase A}} and its association with Tay-Sachs disease=== | === {{Nowrap|Structure of Human β-Hexosaminidase A}} and its association with Tay-Sachs disease=== | ||
Revision as of 07:12, 4 December 2013
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3D Structures of Beta-Hexosaminidase
Updated on 04-December-2013
2xpk, 2w1n – CpBHEXB – Clostridium perfringens
2o4e – CpBHEXB - NMR
2v5c, 2v5d – CpBHEXB catalytic domain
2jh2 – CpBHEXB cohesin-like module
3gh4 – PaBHEX – Paenibacillus
3bmx – BHEX – Bacillus subtilis
1tr9 – VcBHEX – Vibrio cholerae
1hp4 – SpBHEX – Streptomyces plicatus
2ltj – SpnBHEX G5 domain – Streptococcus pneumoniae – NMR
2yl5 – SpnBHEX residues 627-1064
2yl6, 2yll, 3rpm – SpnBHEX catalytic domain
1qba – SmBHEX – Serratia marcescens
3lmy, 1o7a, 1nou – hBHEXB β subunit – human
1o7a - hBHEXB β subunit
2gjx - hBHEXA α+β subunits
3nsm – OfBHEX residues 23-594 – Ostrinia furnacalis
4ais – BtBHEXB – Bacteroides thetaiotaomicron
4g6c – BcBHEX – Burkholderia cenocepacia
4gvf - SeBHEX – Salmonella enterica
3rcn – BHEX – Arthrobacter aurescens
Binary complexes
2gk1 - hBHEXA α+β subunits + NGT
1now - hBHEXB β subunit + GalNAc-isofagomine
1np0 - hBHEXB β subunit + intermediate analog
3gh5, 3gh7 - PaBHEX + GlcNAc
4gvf, 4gvh, 4gvi - SeBHEX + GlcNAc derivative
4hzm – SeBHEX + inhibitor
1m01 - SpBHEX + GlcNAc
1m03, 1m04 - SpBHEX (mutant) + GlcNAc
1jak - SpBHEX + inhibitor
1hp5 - SpBHEX + intermediate analog
2x0y, 2wb5, 2vur - CpBHEXB + inhibitor
2ozn – CpBHEXB + hyaluronidase
3ozo – OfBHEX residues 23-594 + NGT
3ozp – OfBHEX residues 23-594 + PUGNac
3nsn - OfBHEX residues 23-594 + chitotriomycin
2xj7 – BtBHEXB + castanospermine
2wzh, 2wzi - BtBHEXB (mutant) + oxazoline
2vvn - BtBHEX + thiazoline
2x0h - BtBHEXB Michaelis complex
2wca, 2vvs - BtBHEX + PUGNAc
2xm1, 2xm2 - BtBHEXB + lactam derivative
4aiu - BtBHEXB + pyrazole derivative
2w66, 2w67, 2w4x, 2jiw – BtBHEXB + inhibitor
3gs6, 3gsm, 2oxn - VcBHEX + PUGNAc
1y65 - VcBHEX + NAG
4gnv - BcBHEX + NAG
2yl8 – SpnBHEX catalytic domain (mutant) + NAG
4az5, 4az6, 4az7, 4az8, 4azc, 4azg, 4azh – SpnBHEX catalytic domain + inhibitor
4azi – SpnBHEX catalytic domain (mutant) + inhibitor
2yl9, 2yla – SpnBHEX residues 627-1062 (mutant) + NAG
1c7s – SmBHEX + diNAG
1c7t - SmBHEX (mutant) + diNAG
3sur - PaBHEX + NAG derivative
3sus - PaBHEX + GAL-NAG derivative
3sut - PaBHEX + PUGNac
3suu - PaBHEX + GAL-PUGNac
3suv - PaBHEX + NHAC-DNJ
3suw - PaBHEX + NHAC-CAS
References
- ↑ Lemieux MJ, Mark BL, Cherney MM, Withers SG, Mahuran DJ, James MN. Crystallographic structure of human beta-hexosaminidase A: interpretation of Tay-Sachs mutations and loss of GM2 ganglioside hydrolysis. J Mol Biol. 2006 Jun 16;359(4):913-29. Epub 2006 Apr 27. PMID:16698036 doi:http://dx.doi.org/10.1016/j.jmb.2006.04.004
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